Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety (Q27658795)

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15 January 2020

title

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety (English)

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15 January 2020

9

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15 January 2020

1

Alex B Burgin

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15 January 2020

author name string

Olafur T Magnusson

2

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15 January 2020

Jasbir Singh

3

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15 January 2020

Pam Witte

4

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15 January 2020

Bart L Staker

5

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15 January 2020

Jon M Bjornsson

6

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15 January 2020

Margret Thorsteinsdottir

7

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15 January 2020

Sigrun Hrafnsdottir

8

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15 January 2020

Alex S Kiselyov

10

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15 January 2020

Lance J Stewart

11

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15 January 2020

Mark E Gurney

12

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15 January 2020

publication date

27 December 2009

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15 January 2020

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15 January 2020

volume

28

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15 January 2020

issue

1

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15 January 2020

page(s)

63-70

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A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

15 January 2020

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Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

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Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

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cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.

21 January 2018

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Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP‐specific phosphodiesterase: comparison with rolipram

21 January 2018

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Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia.

21 January 2018

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12 December 2020

Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.

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12 December 2020

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

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12 December 2020

Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385.

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12 December 2020

Suncus murinus: a new experimental model in emesis research

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12 December 2020

Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition

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12 December 2020

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

1 reference

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12 December 2020

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

1 reference

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12 December 2020

Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer

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12 December 2020

Gene composer: database software for protein construct design, codon engineering, and gene synthesis

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12 December 2020

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

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12 December 2020

Toward a molecular definition of long-term memory storage

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12 December 2020

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

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12 December 2020

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.

1 reference

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12 December 2020

Discovery of selective PDE4B inhibitors

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12 December 2020

Keynote review: phosphodiesterase-4 as a therapeutic target

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12 December 2020

Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase

1 reference

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12 December 2020

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

1 reference

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12 December 2020

Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain

1 reference

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12 December 2020

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-alpha and leukotriene B4 in a novel human whole blood assay

1 reference

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12 December 2020

Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding.

1 reference

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12 December 2020

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Overview of PDEs and their regulation

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12 December 2020

PDE4 inhibitors: current status

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12 December 2020

The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10

1 reference

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12 December 2020

Development status of second generation PDE4 inhibitors for asthma and COPD: the story so far.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins

1 reference

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12 December 2020

Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor

1 reference

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12 December 2020

Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret

1 reference

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12 December 2020

Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors

1 reference

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12 December 2020

Roflumilast Altana Pharma

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12 December 2020

Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D.

1 reference

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12 December 2020

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

1 reference

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12 December 2020

Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities

1 reference

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12 December 2020

Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases

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12 December 2020

RAR and RXR modulation in cancer and metabolic disease

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12 December 2020

Structural basis for the activity of drugs that inhibit phosphodiesterases

1 reference

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12 December 2020

Correlation between emetic effect of phosphodiesterase 4 inhibitors and their occupation of the high-affinity rolipram binding site in Suncus murinus brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Assessing the emetic potential of PDE4 inhibitors in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Life after PDE4: overcoming adverse events with dual-specificity phosphodiesterase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Improving memory: a role for phosphodiesterases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20037581

12 December 2020

Identifiers

DOI

10.1038/NBT.1598

2 references

Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

15 January 2020

1006878356

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017