The Vps27/Hse1 Complex Is a GAT Domain-Based Scaffold for Ubiquitin-Dependent Sorting (Q27645148)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0033565

ESCRT-0 subunit protein HSE1 YHL002W

1 reference

Ste3p YKL178C

1 reference

ESCRT-0 subunit protein VPS27 YNR006W

1 reference

Gly-Xaa carboxypeptidase YJL172W

1 reference

Carboxypeptidase C PRC1 YMR297W

1 reference

author

Rodolfo Ghirlando

5

0 references

Juan S. Bonifacino

object named as

Juan S Bonifacino

7

0 references

Gerhard Hummer

object named as

Gerhard Hummer

6

0 references

author name string

Gali Prag

1

0 references

Hadiya Watson

2

0 references

Young C Kim

3

0 references

Bridgette M Beach

4

0 references

James H Hurley

The ESCRT complexes: structure and mechanism of a membrane-trafficking network

8

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language of work or name

English

0 references

publication date

June 2007

0 references

published in

Developmental Cell

0 references

volume

12

0 references

issue

6

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page(s)

973-86

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cites work

1 reference

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Interactions of TOM1L1 with the multivesicular body sorting machinery

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The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites

20 March 2017

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Interactions of GGA3 with the ubiquitin sorting machinery

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Tom1, a VHS Domain-containing Protein, Interacts with Tollip, Ubiquitin, and Clathrin

20 March 2017

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Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain

20 March 2017

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Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation

20 March 2017

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TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

20 March 2017

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Crystal structure of the human GGA1 GAT domain

20 March 2017

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Structure and Ubiquitin Binding of the Ubiquitin-interacting Motif

20 March 2017

1 reference

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Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport

20 March 2017

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Structure of the GAT domain of human GGA1: A syntaxin amino-terminal domain fold in an endosomal trafficking adaptor

20 March 2017

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The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs

20 March 2017

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3D domain swapping: as domains continue to swap

20 March 2017

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Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction

20 March 2017

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Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p

20 March 2017

1 reference

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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The CCP4 suite: programs for protein crystallography

20 March 2017

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Mechanisms underlying ubiquitination

20 March 2017

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Maximum-likelihood density modification

20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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Dali: a network tool for protein structure comparison

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

20 March 2017

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GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network

20 March 2017

1 reference

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The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting.

20 March 2017

1 reference

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Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

20 March 2017

1 reference

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Receptor downregulation and multivesicular-body sorting

20 March 2017

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FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes

20 March 2017

1 reference

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Themes and variations on ubiquitylation

20 March 2017

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A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP

20 March 2017

1 reference

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Association with Hrs is required for the early endosomal localization, stability, and function of STAM

20 March 2017

1 reference

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Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes

20 March 2017

1 reference

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Ubiquitin-binding domains

20 March 2017

1 reference

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Ubiquitin-binding domains

7 April 2017

1 reference

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7 April 2017

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The biogenesis of multivesicular endosomes

7 April 2017

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Vps27 recruits ESCRT machinery to endosomes during MVB sorting

7 April 2017

1 reference

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On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation

7 April 2017

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Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

7 April 2017

1 reference

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Protein regulation by monoubiquitin

7 April 2017

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VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae

7 April 2017

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Evolution and function of ubiquitin-like protein-conjugation systems

7 April 2017

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Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies

9 May 2017

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Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains

29 September 2017

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Endosomal and non-endosomal functions of ESCRT proteins

29 September 2017

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The endosome-associated protein Hrs is hexameric and controls cargo sorting as a "master molecule".

29 September 2017

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Structural complexity in ubiquitin recognition.

29 September 2017

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Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery

29 September 2017

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Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain

29 September 2017

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Protein transport from the late Golgi to the vacuole in the yeast Saccharomyces cerevisiae

29 September 2017

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The Hrs/STAM complex in the downregulation of receptor tyrosine kinases

29 September 2017

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Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins

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A protein's final ESCRT.

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GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination.

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Distinct monoubiquitin signals in receptor endocytosis

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Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome.

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PubMed

https://pubmed.ncbi.nlm.nih.gov/17543868

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Computer Modeling of the Membrane Interaction of FYVE Domains

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17543868

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.DEVCEL.2007.04.013

1 reference

1 reference

1 reference

PubMed publication ID

17543868

1 reference