SsDNA endodeoxyribonuclease SAE2 YGL175C (Q27551809)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

1 reference

8 April 2019

nuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

1 reference

8 April 2019

endonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

1 reference

8 April 2019

double-stranded DNA binding

single-stranded DNA endodeoxyribonuclease activity

2 references

2 references

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

1 reference

8 April 2019

endodeoxyribonuclease activity

EXP

1 reference

8 April 2019

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

identical protein binding

EXP

IPI

2 references

protein binding

IPI

1 reference

8 April 2019

Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

IPI

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46946&geneProductId=UniProtKB:P46946

1 reference

10 September 2018

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

1 reference

8 April 2019

TAS

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46946&geneProductId=UniProtKB:P46946

1 reference

10 September 2018

Mre11 complex

1 reference

8 April 2019

Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

meiotic DNA double-strand break processing

biological process

A General Method for Identifying Recessive Diploid-Specific Mutations in Saccharomyces cerevisiae, Its Application to the Isolation of Mutants Blocked at Intermediate Stages of Meiotic Prophase and Characterization of a New Gene SAE2

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

8 April 2019

Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

1 reference

8 April 2019

DNA double-strand break processing involved in repair via synthesis-dependent strand annealing

1 reference

8 April 2019

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

telomere maintenance

1 reference

8 April 2019

Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

DNA catabolic process, endonucleolytic

meiotic DNA double-strand break formation

2 references

1 reference

8 April 2019

Budding yeast Pch2, a widely conserved meiotic protein, is involved in the initiation of meiotic recombination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

telomeric 3' overhang formation

1 reference

8 April 2019

Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

1 reference

8 April 2019

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

1 reference

8 April 2019

DNA double-strand break processing

positive regulation of dephosphorylation

1 reference

8 April 2019

Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

positive regulation of exonuclease activity

1 reference

8 April 2019

Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46946

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference