Chromatin-binding exonuclease XRN1 YGL173C (Q27550704)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22147

Ribosomal protein L2, domain 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22147

Putative 5-3 exonuclease family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

1 reference

14 February 2019

5'-3' exonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

1 reference

14 February 2019

chromatin binding

1 reference

14 February 2019

Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

1 reference

14 February 2019

nucleic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

1 reference

14 February 2019

nuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

1 reference

14 February 2019

5'-3' exoribonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

3 references

14 February 2019

TAS

14 February 2019

Disruption of the gene XRN1, coding for a 5'----3' exoribonuclease, restricts yeast cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

14 February 2019

A 5'----3' exoribonuclease of Saccharomyces cerevisiae: size and novel substrate specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

protein binding

IPI

mRNA binding

HDA

1 reference

14 February 2019

Global analysis of yeast mRNPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

HDA

cell component

P-body

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

14 February 2019

14 February 2019

Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

14 February 2019

Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

perinuclear region of cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

1 reference

14 February 2019

cytoplasmic stress granule

1 reference

14 February 2019

Global analysis of yeast mRNPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

nucleus

1 reference

14 February 2019

Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

cytoplasm

microtubule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

1 reference

14 February 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

1 reference

14 February 2019

eisosome membrane domain/MCC

TAS

1 reference

14 February 2019

Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

3 references

14 February 2019

14 February 2019

Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

14 February 2019

Global analysis of protein localization in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

HDA

biological process

nonfunctional rRNA decay

1 reference

14 February 2019

A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

sno(s)RNA processing

IGI

1 reference

14 February 2019

Processing of the precursors to small nucleolar RNAs and rRNAs requires common components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

traversing start control point of mitotic cell cycle

IGI

1 reference

14 February 2019

A role for KEM1 at the START of the cell cycle in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

rRNA processing

Processing of the precursors to small nucleolar RNAs and rRNAs requires common components

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

14 February 2019

Processing of the precursors to small nucleolar RNAs and rRNAs requires common components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

14 February 2019

positive regulation of transcription initiation from RNA polymerase II promoter

1 reference

14 February 2019

Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

positive regulation of transcription elongation from RNA polymerase II promoter

1 reference

14 February 2019

Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

karyogamy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

1 reference

14 February 2019

nucleic acid phosphodiester bond hydrolysis

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

RNA phosphodiester bond hydrolysis, exonucleolytic

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

mRNA destabilization

1 reference

14 February 2019

Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

negative regulation of macroautophagy

1 reference

14 February 2019

The Exoribonuclease Xrn1 Is a Post-Transcriptional Negative Regulator of Autophagy.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22147

has part(s)

Putative 5-3 exonuclease

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22147

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference