Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism (Q27023275)

David W. Nelson

series ordinal

2

1 reference

Mei-I Yen

series ordinal

3

1 reference

language of work or name

1 reference

March 2015

1 reference

Journal of Lipid Research

published in

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volume

56

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issue

3

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page(s)

489-501

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cites work

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Long-term drug treatment for obesity: a systematic and clinical review

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Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption

21 March 2017

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FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts

21 March 2017

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Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells

21 March 2017

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Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family

21 March 2017

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A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet

21 March 2017

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Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

21 March 2017

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Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

21 March 2017

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Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

21 March 2017

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Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity

21 March 2017

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Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein

21 March 2017

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A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters

21 March 2017

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Decreased Hepatic Triglyceride Accumulation and Altered Fatty Acid Uptake in Mice with Deletion of the Liver Fatty Acid-binding Protein Gene

21 March 2017

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Identification of the major intestinal fatty acid transport protein

21 March 2017

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Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

21 March 2017

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Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets

21 March 2017

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Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice

21 March 2017

1 reference

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Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

21 March 2017

1 reference

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Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity

21 March 2017

1 reference

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Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats

21 March 2017

1 reference

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DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes

21 March 2017

1 reference

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Acyl-coenzyme A synthetases in metabolic control

21 March 2017

1 reference

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The biogenesis of chylomicrons

21 March 2017

1 reference

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Lipopenia and skin barrier abnormalities in DGAT2-deficient mice

21 March 2017

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MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine

21 March 2017

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Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2

21 March 2017

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Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes

21 March 2017

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Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.

21 March 2017

1 reference

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Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism

28 September 2017

1 reference

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Cideb facilitates the lipidation of chylomicrons in the small intestine

28 September 2017

1 reference

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Acyl-CoA metabolism and partitioning

28 September 2017

1 reference

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Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Intestinal Cgi-58 deficiency reduces postprandial lipid absorption

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

New and emerging regulators of intestinal lipoprotein secretion

28 September 2017

1 reference

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Direct comparison of mice null for liver or intestinal fatty acid-binding proteins reveals highly divergent phenotypic responses to high fat feeding

28 September 2017

1 reference

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Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors

28 September 2017

1 reference

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Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption

28 September 2017

1 reference

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Intestinal caveolin-1 is important for dietary fatty acid absorption

28 September 2017

1 reference

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Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol

28 September 2017

1 reference

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Intestinal acyl-CoA:diacylglycerol acyltransferase 2 overexpression enhances postprandial triglyceridemic response and exacerbates high fat diet-induced hepatic triacylglycerol storage

28 September 2017

1 reference

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Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice

28 September 2017

1 reference

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Biochemistry and pathophysiology of intravascular and intracellular lipolysis

28 September 2017

1 reference

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Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.

28 September 2017

1 reference

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CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin

28 September 2017

1 reference

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Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling

28 September 2017

1 reference

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DGAT1 mutation is linked to a congenital diarrheal disorder

28 September 2017

1 reference

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Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying

28 September 2017

1 reference

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Role of the gut in lipid homeostasis

28 September 2017

1 reference

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Lumenal lipid metabolism: implications for lipoprotein assembly

28 September 2017

1 reference

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Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.

28 September 2017

1 reference

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Dietary triacylglycerol structure and its role in infant nutrition

28 September 2017

1 reference

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Evidence that diacylglycerol acyltransferase 1 (DGAT1) has dual membrane topology in the endoplasmic reticulum of HepG2 cells

28 September 2017

1 reference

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Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain

28 September 2017

1 reference

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Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling

28 September 2017

1 reference

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The acyl coenzymeA:monoacylglycerol acyltransferase 3 (MGAT3) gene is a pseudogene in mice but encodes a functional enzyme in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Topological Orientation of Acyl-CoA:Diacylglycerol Acyltransferase-1 (DGAT1) and Identification of a Putative Active Site Histidine and the Role of the N Terminus in Dimer/Tetramer Formation

28 September 2017

1 reference

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GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis

28 September 2017

1 reference

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Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- mice

28 September 2017

1 reference

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Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion

28 September 2017

1 reference

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Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

28 September 2017

1 reference

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Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Intestinal absorption of long-chain fatty acids: evidence and uncertainties

28 September 2017

1 reference

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Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

28 September 2017

1 reference

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Structural and functional analysis of fatty acid-binding proteins.

28 September 2017

1 reference

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Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism

28 September 2017

1 reference

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Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

28 September 2017

1 reference

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Intestinal lipoprotein overproduction in insulin-resistant states

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

The emerging functions and mechanisms of mammalian fatty acid-binding proteins

28 September 2017

1 reference

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Metabolism of apical versus basolateral sn-2-monoacylglycerol and fatty acids in rodent small intestine

28 September 2017

1 reference

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The molecular basis of retinoid absorption: a genetic dissection

28 September 2017

1 reference

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Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Cellular fatty acid uptake: the contribution of metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Enzymes of triacylglycerol synthesis and their regulation

28 September 2017

1 reference

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Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1

28 September 2017

1 reference

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Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340298

Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?

28 September 2017

1 reference

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Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models

28 September 2017

1 reference

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Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.

28 September 2017

1 reference

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Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands

28 September 2017

1 reference

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Inhibitory effect of monoacylglycerol on fatty acid uptake into rat intestinal epithelial cells

28 September 2017

1 reference

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The role of apolipoprotein A-IV in the regulation of food intake

28 September 2017

1 reference

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Intestinal lipid absorption and transport

28 September 2017

1 reference

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APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation

28 September 2017

1 reference

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The fatty acid transport function of fatty acid-binding proteins

28 September 2017

1 reference

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Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

28 September 2017

1 reference

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The liver fatty acid binding protein--comparison of cavity properties of intracellular lipid-binding proteins.

28 September 2017

1 reference

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Biosynthesis of triacylglycerols

28 September 2017

1 reference

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A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.

28 September 2017

1 reference

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Enzymes of Glycerolipid Synthesis in Eukaryotes

28 September 2017

1 reference

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The Monoglyceride Pathway of Fat Absorption in Man*

28 September 2017

1 reference

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Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranes

28 September 2017

1 reference

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Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related

28 September 2017

1 reference

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Intestinal metabolism of plasma free fatty acids. Intracellular compartmentation and mechanisms of control

28 September 2017

1 reference

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Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases

28 September 2017

1 reference

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Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets

31 May 2018

1 reference

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Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.

31 May 2018

1 reference

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Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency.

31 May 2018

1 reference

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The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters

31 May 2018

1 reference

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Triacylglycerol synthesis by purified triacylglycerol synthetase of rat intestinal mucosa. Role of acyl-CoA acyltransferase

31 May 2018

1 reference

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Thermic effect of feeding carbohydrate, fat, protein and mixed meal in lean and obese subjects

31 May 2018

1 reference

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Utilization of 2-monoacylglycerols for phosphatidylcholine biosynthesis in the intestine

31 May 2018

1 reference

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Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver

31 May 2018

1 reference

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The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice.

21 January 2018

1 reference

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Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis.

21 January 2018

1 reference

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Catalytic properties of MGAT3, a putative triacylgycerol synthase.

21 January 2018

1 reference

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DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis

21 January 2018

1 reference

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A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging

21 January 2018

1 reference

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Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1.

21 January 2018

1 reference

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Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production.

21 January 2018

1 reference

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Signals that regulate food intake and energy homeostasis

21 January 2018

1 reference

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Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity

21 January 2018

1 reference

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A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity.

21 January 2018

1 reference

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Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor

21 January 2018

1 reference

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Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

21 January 2018

1 reference

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Liver Fatty Acid-binding Protein Initiates Budding of Pre-chylomicron Transport Vesicles from Intestinal Endoplasmic Reticulum

21 January 2018

1 reference

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Common mechanisms of monoacylglycerol and fatty acid uptake by human intestinal Caco-2 cells

21 January 2018

1 reference

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Intestinal triacylglycerol storage pool size changes under differing physiological conditions

28 November 2018

1 reference

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Triacylglycerol synthesis by an sn-1,2(2,3)-diacylglycerol transacylase from rat intestinal microsomes

28 November 2018

1 reference

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Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Assay of acyl-CoA:monoglyceride acyltransferase from rat small intestine using continuous recording spectrophotometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Apical distribution of fatty acid esterification capacity along the villus-crypt unit of rat jejunum

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Intestinal absorption of fat

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Faecal Fat Excretion, Diarrhea, and Subjective Complaints with Highly Dosed Oral Fat Intake

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Absorption of monoacylglycerols by small intestinal brush border membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

CD36 enhances fatty acid uptake by increasing the rate of intracellular esterification but not transport across the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

A re-examination of the fate of glyceride-glycerol in neutral lipid absorption and transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Meal-induced thermogenesis and obesity: is a fat meal a risk factor for fat gain in children?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Origin of triacylglycerol moiety of plasma very low density lipoproteins in the rat: structural studies

1 reference

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12 December 2020

Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Hepatic monoacylglycerol acyltransferase. Characterization of an activity associated with the suckling period in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Lipoproteins associated with the Golgi apparatus isolated from epithelial cells of rat small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Intestinal triglycerides are derived from both endogenous and exogenous sources

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Adipose monoacylglycerol:acyl-coenzyme A acyltransferase activity in the white-throated sparrow (Zonotrichia albicollis): characterization and function in a migratory bird

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Effect of increasing lipid loads on the ability of the endoplasmic reticulum to transport lipid to the Golgi

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

The separation of the α-glycerophosphate and monoglyceride pathways in the intestinal biosynthesis of triglycerides

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Comparison of plasma membrane FABP and mitochondrial isoform of aspartate aminotransferase from rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

The absorption in the rat of a 1,3-dioleyl-2-deuteriostearyl glyceride-C14 and a 1-monodeuteriostearyl glyceride-C14

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Metabolism of lipides

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231105

12 December 2020

Identifiers

0 references

1 reference

PubMed publication ID

25231105

1 reference