Brain insulin resistance in Alzheimer's disease and its potential treatment with GLP-1 analogs (Q27012801)

language of work or name

1 reference

2014

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Neurodegenerative disease management

published in

1 reference

volume

4

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issue

1

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page(s)

31-40

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Ushering in the study and treatment of preclinical Alzheimer disease

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Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence

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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

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Insulin in the brain: there and back again

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Alzheimer disease: new concepts on its neurobiology and the clinical role imaging will play

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Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

21 March 2017

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Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit

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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

21 March 2017

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RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet

21 March 2017

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The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

7 April 2017

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Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.

7 April 2017

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Effectiveness of exercise on cognitive impairment and Alzheimer's disease

28 September 2017

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Exenatide and the treatment of patients with Parkinson's disease

28 September 2017

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Secular changes in the age-specific prevalence of diabetes among U.S. adults: 1988-2010

28 September 2017

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Secular changes in U.S. Prediabetes prevalence defined by hemoglobin A1c and fasting plasma glucose: National Health and Nutrition Examination Surveys, 1999-2010

28 September 2017

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Neuroprotective effects of D-Ala(2)GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model

28 September 2017

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Evaluating second-line treatment options for type 2 diabetes: focus on secondary effects of GLP-1 agonists and DPP-4 inhibitors

28 September 2017

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Nutrition and neurodegeneration: epidemiological evidence and challenges for future research

28 September 2017

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Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration.

28 September 2017

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Alzheimer's therapeutics: continued clinical failures question the validity of the amyloid hypothesis-but what lies beyond?

28 September 2017

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Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?

28 September 2017

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28 September 2017

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Drug repositioning for Alzheimer's disease.

28 September 2017

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A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer.

28 September 2017

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Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus.

28 September 2017

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Insulin in the brain: sources, localization and functions.

28 September 2017

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Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection

28 September 2017

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Insulin and Alzheimer's disease: untangling the web.

28 September 2017

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Long night's journey into the day: amyloid-β imaging in Alzheimer's disease

28 September 2017

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Effects of glucagon-like peptide-1 receptor agonists on body weight: a meta-analysis

28 September 2017

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Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders

28 September 2017

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

28 September 2017

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

28 September 2017

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Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study

28 September 2017

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Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

28 September 2017

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Effect of intranasal insulin on cognitive function: a systematic review

28 September 2017

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The neuropathological profile of mild cognitive impairment (MCI): a systematic review.

28 September 2017

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Rosiglitazone and pioglitazone for the treatment of Alzheimer's disease

28 September 2017

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Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

28 September 2017

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Evidence for ordering of Alzheimer disease biomarkers

28 September 2017

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Liraglutide for the treatment of type 2 diabetes: a clinical update

28 September 2017

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Mediterranean diet in predementia and dementia syndromes.

28 September 2017

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Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

28 September 2017

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Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

28 September 2017

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Does a Pro-Inflammatory Process Precede Alzheimers Disease and Mild Cognitive Impairment?

28 September 2017

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Preproglucagon neurons project widely to autonomic control areas in the mouse brain.

28 September 2017

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Epidemiology of Alzheimer disease

28 September 2017

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Thiazolidinediones and risk of heart failure in patients with or at high risk of type 2 diabetes mellitus: a meta-analysis and meta-regression analysis of placebo-controlled randomized clinical trials.

28 September 2017

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Two Distinct Amyloid β-Protein (Aβ) Assembly Pathways Leading to Oligomers and Fibrils Identified by Combined Fluorescence Correlation Spectroscopy, Morphology, and Toxicity Analyses

28 September 2017

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Toward a Molecular Theory of Early and Late Events in Monomer to Amyloid Fibril Formation

28 September 2017

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Neuroinflammatory processes in Alzheimer's disease

28 September 2017

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Pathogenesis of insulin resistance in skeletal muscle

28 September 2017

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Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

28 September 2017

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Omega-3 fatty acids and dementia.

28 September 2017

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Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

28 September 2017

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Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders

28 September 2017

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Insulin sensitivity: modulation by nutrients and inflammation

28 September 2017

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Phosphorylation of IRS proteins, insulin action, and insulin resistance

28 September 2017

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Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

28 September 2017

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Insulin in Brain and Other Extrapancreatic Tissues of Vertebrates and Nonvertebrates

28 September 2017

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A longitudinal follow-up of 550 mild cognitive impairment patients: evidence for large conversion to dementia rates and detection of major risk factors involved

28 September 2017

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The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.

31 May 2018

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Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases

31 May 2018

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Peripheral amyloid-beta levels regulate amyloid-beta clearance from the central nervous system

31 May 2018

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GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes

31 May 2018

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Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype

31 May 2018

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Insulin gene expression and insulin synthesis in mammalian neuronal cells

31 May 2018

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Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system.

31 May 2018

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31 May 2018

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Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type

31 May 2018

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Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.

31 May 2018

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21 January 2018

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21 January 2018

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Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes

21 January 2018

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Pomegranate flower: a unique traditional antidiabetic medicine with dual PPAR-alpha/-gamma activator properties

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Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial

21 January 2018

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Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system.

21 January 2018

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The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

21 January 2018

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Dementia is associated with insulin resistance in patients with Parkinson's disease

21 January 2018

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Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

21 January 2018

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Entry of exendin-4 into brain is rapid but may be limited at high doses

28 November 2018

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12 December 2020

2013 Alzheimer's disease facts and figures

1 reference

https://pubmed.ncbi.nlm.nih.gov/24640977

12 December 2020

Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/24640977

12 December 2020

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24640977

12 December 2020

Identifiers

DOI

10.2217/NMT.13.73

1 reference

1 reference

1 reference

PubMed publication ID

24640977

1 reference