Recent progress in structure-based anti-influenza drug design (Q26863710)

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5 February 2020

title

Recent progress in structure-based anti-influenza drug design (English)

2 references

PubMed

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5 February 2020

3

1 reference

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5 February 2020

author name string

Juan Du

series ordinal

1

2 references

Crossref

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5 February 2020

Timothy A Cross

series ordinal

2

1 reference

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5 February 2020

language of work or name

1 reference

13 June 2012

1 reference

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5 February 2020

2 references

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5 February 2020

volume

17

2 references

PubMed

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5 February 2020

issue

19-20

2 references

PubMed

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5 February 2020

page(s)

1111-1120

1 reference

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M2 protein from influenza A: from multiple structures to biophysical and functional insights

5 February 2020

cites work

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Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

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Structure and mechanism of the M2 proton channel of influenza A virus

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Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

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Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

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Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase

21 March 2017

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Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

21 March 2017

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Structures of Receptor Complexes of a North American H7N2 Influenza Hemagglutinin with a Loop Deletion in the Receptor Binding Site

21 March 2017

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Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

21 March 2017

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Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center

21 March 2017

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The structure of a biologically active influenza virus ribonucleoprotein complex

21 March 2017

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Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

21 March 2017

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Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue

21 March 2017

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Structural basis for dsRNA recognition by NS1 protein of influenza A virus

21 March 2017

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Structural basis for suppression of a host antiviral response by influenza A virus

21 March 2017

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The structural basis for an essential subunit interaction in influenza virus RNA polymerase

21 March 2017

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Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus

21 March 2017

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Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design

21 March 2017

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21 March 2017

Viral membrane fusion

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The structural basis for cap binding by influenza virus polymerase subunit PB2

21 March 2017

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Structural basis for the function and inhibition of an influenza virus proton channel

21 March 2017

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Backbone Structure of the Amantadine-Blocked Trans-Membrane Domain M2 Proton Channel from Influenza A Virus

21 March 2017

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Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

21 March 2017

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The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA

21 March 2017

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The structure and receptor binding properties of the 1918 influenza hemagglutinin

21 March 2017

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Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2)

21 March 2017

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X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs

21 March 2017

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Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomer

21 March 2017

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Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1

21 March 2017

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A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies

21 March 2017

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The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor

21 March 2017

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Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin

21 March 2017

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Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes

21 March 2017

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A novel influenza A virus mitochondrial protein that induces cell death.

21 March 2017

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Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): mechanism of action

21 March 2017

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The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue

21 March 2017

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The multifunctional NS1 protein of influenza A viruses

21 March 2017

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The war against influenza: discovery and development of sialidase inhibitors

21 March 2017

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Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution

21 March 2017

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Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus

21 March 2017

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Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo

21 March 2017

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Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts

21 March 2017

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Rational design of potent sialidase-based inhibitors of influenza virus replication

21 March 2017

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Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus

7 April 2017

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E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors

7 April 2017

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Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel

28 September 2017

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Mechanism of 150-cavity formation in influenza neuraminidase

28 September 2017

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Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus

28 September 2017

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Influenza virus assembly and budding

28 September 2017

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Discovery of highly potent agents against influenza A virus

28 September 2017

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High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity

28 September 2017

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Structure-based design of NS2 mutants for attenuated influenza A virus vaccines

28 September 2017

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Identification of influenza A nucleoprotein as an antiviral target

28 September 2017

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Discovery of novel 1-phenyl-cycloalkane carbamides as potent and selective influenza fusion inhibitors.

28 September 2017

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Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities

28 September 2017

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Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses

28 September 2017

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Potential drug-like inhibitors of Group 1 influenza neuraminidase identified through computer-aided drug design

28 September 2017

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Identification of hits as matrix-2 protein inhibitors through the focused screening of a small primary amine library

28 September 2017

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Structures of influenza A proteins and insights into antiviral drug targets.

28 September 2017

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Combinatorial design of avian influenza neuraminidase inhibitors containing pyrrolidine core with a reduced susceptibility to viral drug resistance

28 September 2017

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Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus

28 September 2017

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Large-scale sequence analysis of M gene of influenza A viruses from different species: mechanisms for emergence and spread of amantadine resistance.

28 September 2017

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Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus

28 September 2017

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Design of oseltamivir analogs inhibiting neuraminidase of avian influenza virus H5N1.

28 September 2017

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Emerging antiviral targets for influenza A virus.

28 September 2017

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A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase.

28 September 2017

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Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 season

28 September 2017

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On the structure-based design of novel inhibitors of H5N1 influenza A virus neuraminidase (NA).

28 September 2017

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Novel influenza virus NS1 antagonists block replication and restore innate immune function

28 September 2017

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Design of multi-binding-site inhibitors, ligand efficiency, and consensus screening of avian influenza H5N1 wild-type neuraminidase and of the oseltamivir-resistant H274Y variant

28 September 2017

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The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding

28 September 2017

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Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase.

28 September 2017

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A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine.

28 September 2017

1 reference

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Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Calculation of protein-ligand binding affinities.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

High levels of adamantane resistance among influenza A (H3N2) viruses and interim guidelines for use of antiviral agents--United States, 2005-06 influenza season.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Restriction of viral replication by mutation of the influenza virus matrix protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

In vitro characterization of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Influenza virus matrix protein is the major driving force in virus budding.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Resistance of influenza viruses to neuraminidase inhibitors--a review.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Global epidemiology of influenza: past and present.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Growth impairment resulting from expression of influenza virus M2 protein in Saccharomyces cerevisiae: identification of a novel inhibitor of influenza virus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Variation of influenza A, B, and C viruses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

The molecular biology of influenza virus pathogenicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Comparison of complete amino acid sequences and receptor-binding properties among 13 serotypes of hemagglutinins of influenza A viruses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Proposed lead molecules against Hemagglutinin of avian influenza virus (H5N1).

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Peptide-mediated interference with influenza A virus polymerase

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Nuclear transport of influenza virus ribonucleoproteins: the viral matrix protein (M1) promotes export and inhibits import

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Are the 5' ends of influenza viral mRNAs synthesized in vivo donated by host mRNAs?

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Three new powerful oseltamivir derivatives for inhibiting the neuraminidase of influenza virus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Computational design of novel, high-affinity neuraminidase inhibitors for H5N1 avian influenza virus

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Rational design of Tamiflu derivatives targeting at the open conformation of neuraminidase subtype 1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Update: drug susceptibility of swine-origin influenza A (H1N1) viruses, April 2009.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459301

10.1016/J.DRUDIS.2012.06.002

28 November 2018

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22704956%20AND%20SRC:MED&resulttype=core&format=json

release_zxi3lct6kvf2vipt6dwl6jispm

5 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zxi3lct6kvf2vipt6dwl6jispm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22704956%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

22704956

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22704956%20AND%20SRC:MED&resulttype=core&format=json