Pharmacological Treatments Inhibiting Levodopa-Induced Dyskinesias in MPTP-Lesioned Monkeys: Brain Glutamate Biochemical Correlates (Q26852311)

language of work or name

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2014

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published in

Frontiers in Neurology

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volume

5

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page(s)

144

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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

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AFQ056 in Parkinson patients with levodopa-induced dyskinesia: 13-week, randomized, dose-finding study

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New pharmacological avenues for the treatment of L-DOPA-induced dyskinesias in Parkinson's disease: targeting glutamate and adenosine receptors

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Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation.

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A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys

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Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling

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Low doses of sarizotan reduce dyskinesias and maintain antiparkinsonian efficacy of L-Dopa in parkinsonian monkeys

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Treatment of levodopa-induced motor complications

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Molecular mechanisms of L-DOPA-induced dyskinesia

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Association between AKT1 gene and Parkinson's disease: a protective haplotype

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Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

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The Akt-GSK-3 signaling cascade in the actions of dopamine

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Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies.

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Role of the ERK pathway in psychostimulant-induced locomotor sensitization.

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The 'magic' of L-dopa: why is it the gold standard Parkinson's disease therapy?

28 September 2017

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Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum

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Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury

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Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors

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The contribution of the MPTP-treated primate model to the development of new treatment strategies for Parkinson's disease

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Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia

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Chronic L-DOPA treatment increases extracellular glutamate levels and GLT1 expression in the basal ganglia in a rat model of Parkinson's disease

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Calcium-permeable AMPA receptors are involved in the induction and expression of l-DOPA-induced dyskinesia in Parkinson's disease

21 January 2018

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Higher free D-aspartate and N-methyl-D-aspartate levels prevent striatal depotentiation and anticipate L-DOPA-induced dyskinesia.

21 January 2018

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Rebalance of striatal NMDA/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2-like dopamine agonist treatment in experimental Parkinson's disease

21 January 2018

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GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease

21 January 2018

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Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease

21 January 2018

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Systemic administration of an mGluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesias in a rodent model of Parkinson's disease

21 January 2018

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Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease

21 January 2018

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Metabotropic glutamate receptor II in the brains of Parkinsonian patients

21 January 2018

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Activation of group III metabotropic glutamate receptors presynaptically reduces both GABAergic and glutamatergic transmission in the rat globus pallidus

21 January 2018

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Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.

21 January 2018

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Differential effect of chronic dopaminergic treatment on dopamine D1 and D2 receptors in the monkey brain in MPTP-induced parkinsonism

21 January 2018

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21 January 2018

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Mu- and delta-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

21 January 2018

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Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia

21 January 2018

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Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.

21 January 2018

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Dopamine depletion and subsequent treatment with L-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum

21 January 2018

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Effect of chronic l-DOPA treatment on 5-HT(1A) receptors in parkinsonian monkey brain

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Basal ganglia serotonin 1B receptors in parkinsonian monkeys with L-DOPA-induced dyskinesia

21 January 2018

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Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys

21 January 2018

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Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism.

21 January 2018

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Non-NMDA receptor-mediated mechanisms are involved in levodopa-induced motor response alterations in Parkinsonian rats

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Glycine site agonists of the N-methyl-D-aspartate receptor and Parkinson's disease: a hypothesis

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Functional neurochemistry of the basal ganglia

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The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in L-Dopa-treated parkinsonian monkeys

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12 December 2020

Toward an understanding of the role of glutamate in experimental parkinsonism: Agonist‐sensitive sites in the basal ganglia

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12 December 2020

Long-term treatment with l-DOPA and an mGlu5 receptor antagonist prevents changes in brain basal ganglia dopamine receptors, their associated signaling proteins and neuropeptides in parkinsonian monkeys

1 reference

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12 December 2020

[3H]spiperone binding, dopamine and HVA concentrations in Parkinson's disease and supranuclear palsy

1 reference

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12 December 2020

Glutamate release inhibition ineffective in levodopa-induced motor complications

1 reference

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12 December 2020

Behavioral and biochemical effect of chronic treatment with D-1 and/or D-2 dopamine agonists in MPTP monkeys

1 reference

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12 December 2020

Brain 5-HT(2A) receptors in MPTP monkeys and levodopa-induced dyskinesias

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12 December 2020

Levodopa-induced dopamine receptor hypersensitivity

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12 December 2020

release_whqed5vcb5cr3nhcbgn3y57doe

Identifiers

DOI

10.3389/FNEUR.2014.00144

0 references

Fatcat ID

0 references

1 reference

PubMed publication ID

25140165

1 reference