The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity (Q24654198)

1

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Mohamed Abdouh

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Jocelyn David

3

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Marie-Pier Champagne

4

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José Ferreira

5

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Francis Rodier

Acetylation is indispensable for p53 activation

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language of work or name

English

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publication date

14 January 2009

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published in

Journal of Neuroscience

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volume

29

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issue

2

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page(s)

529-42

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cites work

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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

7 April 2017

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7 April 2017

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

7 April 2017

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p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition

7 April 2017

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Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease

7 April 2017

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Ink4a/Arf expression is a biomarker of aging

7 April 2017

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Biological roles and mechanistic actions of co-repressor complexes

7 April 2017

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Age-dependent changes in the expression of matrix components in the mouse eye

7 April 2017

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Mitochondria, oxidants, and aging

7 April 2017

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Intracellular amyloid-beta in Alzheimer's disease

7 April 2017

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Polycomb silencers control cell fate, development and cancer

7 April 2017

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

7 April 2017

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Oxidative stress and neurodegeneration: where are we now?

7 April 2017

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The antioxidant function of the p53 tumor suppressor

7 April 2017

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

7 April 2017

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

7 April 2017

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

7 April 2017

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p53 mutant mice that display early ageing-associated phenotypes

7 April 2017

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Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice

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HDAC3: taking the SMRT-N-CoRrect road to repression

28 September 2017

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p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.

28 September 2017

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28 September 2017

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Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression

28 September 2017

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Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.

28 September 2017

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Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription

28 September 2017

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Stem cells and cancer; the polycomb connection

28 September 2017

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

28 September 2017

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Oncogenic ras and p53 cooperate to induce cellular senescence

28 September 2017

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Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

28 September 2017

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APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

28 September 2017

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28 September 2017

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Delayed ageing through damage protection by the Arf/p53 pathway

28 November 2018

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Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span

28 November 2018

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28 November 2018

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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

28 November 2018

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Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

28 November 2018

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Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise

28 November 2018

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The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.

28 November 2018

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Microsomal lipid peroxidation

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19144853

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Risk factors for age-related cortical, nuclear, and posterior subcapsular cataracts. The Italian-American Cataract Study Group

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19144853

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19144853

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.5303-08.2009

1 reference

1 reference

1 reference

PubMed publication ID

19144853

1 reference