Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6 (Q24652510)

cyclin dependent kinase inhibitor 2A

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negative regulation of cyclin-dependent protein serine/threonine kinase activity

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Cyclin-dependent kinase 1

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Cyclin dependent kinase inhibitor 2C

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Cyclin-dependent kinase 4

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Cyclin A1

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Cyclin-dependent kinase 2

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Cyclin A2

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Cyclin dependent kinase inhibitor 2D

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Cyclin E2

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Cyclin-dependent kinase 6

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Cyclin D2

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Cyclin E1

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Tumor suppressor ARF

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author name string

H Hirai

1

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M F Roussel

2

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J Y Kato

3

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R A Ashmun

4

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C J Sherr

Molecular and Cellular Biology

5

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language of work or name

English

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publication date

May 1995

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published in

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volume

15

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issue

5

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page(s)

2672-81

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cites work

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

7 April 2017

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Identification of G1 kinase activity for cdk6, a novel cyclin D partner

7 April 2017

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

7 April 2017

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

7 April 2017

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

7 April 2017

1 reference

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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

7 April 2017

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A family of human cdc2-related protein kinases

7 April 2017

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The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

7 April 2017

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WAF1, a potential mediator of p53 tumor suppression

7 April 2017

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High-efficiency transformation of mammalian cells by plasmid DNA

7 April 2017

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Cyclin D1 is a nuclear protein required for cell cycle progression in G1

7 April 2017

1 reference

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Physical interaction of the retinoblastoma protein with human D cyclins

7 April 2017

1 reference

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

7 April 2017

1 reference

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

7 April 2017

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p21 is a universal inhibitor of cyclin kinases

7 April 2017

1 reference

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A cell cycle regulator potentially involved in genesis of many tumor types

7 April 2017

1 reference

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

7 April 2017

1 reference

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Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation

7 April 2017

1 reference

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

7 April 2017

1 reference

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Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

7 April 2017

1 reference

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Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

7 April 2017

1 reference

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D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

7 April 2017

1 reference

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Production of high-titer helper-free retroviruses by transient transfection

7 April 2017

1 reference

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7 April 2017

1 reference

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Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

7 April 2017

1 reference

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D-type cyclin-dependent kinase activity in mammalian cells

7 April 2017

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DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1

7 April 2017

1 reference

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Germline p16 mutations in familial melanoma

28 September 2017

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Mutations and altered expression of p16INK4 in human cancer.

28 September 2017

1 reference

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Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Subcellular localization of glycoproteins encoded by the viral oncogene v-fms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Quantitative variation of the common acute lymphoblastic leukemia antigen (gp100) on leukemic marrow blasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

p21-containing cyclin kinases exist in both active and inactive states

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

The macrophage colony-stimulating factor, CSF-1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Role of myc in the abrogation of IL3 dependence of myeloid FDC-P1 cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230497

The regulation of mononuclear phagocyte entry into S phase by the colony stimulating factor CSF-1

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/7739547

12 December 2020

Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/7739547

12 December 2020

P16 gene in uncultured tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/7739547

12 December 2020

Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/7739547

12 December 2020

Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB

1 reference

https://pubmed.ncbi.nlm.nih.gov/7739547

12 December 2020

Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/7739547

12 December 2020

Identifiers

DOI

10.1128/MCB.15.5.2672

1 reference

1 reference

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PubMed publication ID

7739547

1 reference