Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors (Q24650641)

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Language	Label	Description	Also known as
English	Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors	scientific article

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scholarly article

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Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors (English)

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author name string

P Malherbe

1

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R Masciadri

2

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R D Norcross

3

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F Knoflach

4

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C Kratzeisen

5

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M-T Zenner

6

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Y Kolb

7

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A Marcuz

8

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J Huwyler

9

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T Nakagawa

10

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R H P Porter

11

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A W Thomas

12

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J G Wettstein

13

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A J Sleight

14

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W Spooren

15

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E P Prinssen

16

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language of work or name

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publication date

June 2008

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British Journal of Pharmacology

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154

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4

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797-811

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Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

1 reference

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Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

1 reference

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7 April 2017

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

2 references

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7 April 2017

https://api.crossref.org/works/10.1038%2FBJP.2008.135

7 January 2021

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Effects of GABAB receptor ligands in animal tests of depression and anxiety.

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28 September 2017

Differential compartmentalization and distinct functions of GABAB receptor variants

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The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: a review of pharmacological and genetic studies in the mouse

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Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area

1 reference

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28 September 2017

GABAergic hypotheses of anxiety and depression: focus on GABA-B receptors

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GABAB receptor: a site of therapeutic benefit

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

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28 September 2017

In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor

1 reference

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Molecular structure and physiological functions of GABA(B) receptors

1 reference

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28 September 2017

The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor

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28 September 2017

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines

1 reference

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28 September 2017

Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.

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Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain

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N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

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GABA(B) receptors as potential therapeutic targets

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28 September 2017

No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.

1 reference

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GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

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Role of gamma-aminobutyric acid in antipanic drug efficacy

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GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area

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Effects of GABAB receptor ligands in rodent tests of anxiety-like behavior

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The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons

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The positive allosteric modulator GS39783 enhances GABA(B) receptor-mediated inhibition of cyclic AMP formation in rat striatum in vivo

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Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors

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Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains

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Peripheral GABAB agonists stimulate gastric acid secretion in mice.

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The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor

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Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

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https://pubmed.ncbi.nlm.nih.gov/18536733

12 December 2020

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Identifiers

10.1038/BJP.2008.135

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