ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate (Q24632241)

1

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Aline Martin

2

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Anne-Marie Hedge

3

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Marc K Drezner

4

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Peter S N Rowe

American Journal of Physiology - Renal Physiology

5

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language of work or name

English

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publication date

March 2011

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published in

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volume

300

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issue

3

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page(s)

F783-91

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cites work

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MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM

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Matrix extracellular phosphoglycoprotein inhibits phosphate transport

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Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone

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Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator

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Phosphorylation of osteopontin is required for inhibition of calcium oxalate crystallization

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Bone sialoprotein binding to matrix metalloproteinase-2 alters enzyme inhibition kinetics

27 September 2017

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Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer

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Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia

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Urinary acidification assessed by simultaneous furosemide and fludrocortisone treatment: an alternative to ammonium chloride

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Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

27 September 2017

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Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

27 September 2017

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Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

27 September 2017

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Increased cathepsin D release by Hyp mouse osteoblast cells

27 September 2017

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Altered cathepsin D metabolism in PHEX antisense human osteoblast cells

27 September 2017

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Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)

27 September 2017

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Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets

27 September 2017

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The wrickkened pathways of FGF23, MEPE and PHEX.

27 September 2017

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MEPE has the properties of an osteoblastic phosphatonin and minhibin.

27 September 2017

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Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport

27 September 2017

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Effects of PHEX antisense in human osteoblast cells

27 September 2017

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Relation between bone mineralization, Ca absorption, and plasma Ca in phosphonate-treated rats

27 September 2017

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DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype

27 September 2017

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MEPE's diverse effects on mineralization

30 May 2018

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DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix.

30 May 2018

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Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX.

30 May 2018

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30 May 2018

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Mechanism of phosphaturia elicited by administration of phosphonoformate in vivo

30 May 2018

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Dual action of phosphonoformic acid on Na(+)-phosphate cotransport in opossum kidney cells

30 May 2018

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Changes in the renal and extrarenal handling of phosphate induced by disodium etidronate (EHDP) in man.

30 May 2018

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Inhibition of Na+-Pi cotransporter in small gut brush border by phosphonocarboxylic acids.

30 May 2018

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Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression

19 June 2018

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Inhibition of MEPE cleavage by Phex.

21 January 2018

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Phosphorylated osteopontin peptides suppress crystallization by inhibiting the growth of calcium oxalate crystals

21 January 2018

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A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

21 January 2018

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Morphological conversion of calcium oxalate crystals into stones is regulated by osteopontin in mouse kidney

21 January 2018

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Phosphate transport: molecular basis, regulation and pathophysiology.

21 January 2018

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Dentin Alteration of Deciduous Teeth in Human Hypophosphatemic Rickets

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Effects of impaired functional domains of osteopontin on renal crystal formation: Analyses of OPN transgenic and OPN knockout mice

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Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases

28 November 2018

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28 November 2018

Hypophosphatemic rickets

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12 December 2020

Action of 1,25-dihydroxyvitamin D3 and a diphosphonate on calcium metabolism in rats

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Effect of diphosphonate treatment on phosphate transport by renal brush border vesicles

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Tubular handling of phosphate along the nephron of thyroparathyroidectomized rats injected with ethane-1-hydroxy-1,1-diphosphonate

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Phosphonocarboxylic acids as specific inhibitors of Na+-dependent transport of phosphate across renal brush border membrane

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12 December 2020

Comparative effects of intravenous diphosphonates on calcium and skeletal metabolism in man

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Diphosphonates and phosphate homoeostasis in man

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12 December 2020

Phosphate transport in brush border membranes from uremic rats. Response to phosphonoformic acid

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12 December 2020

Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption

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12 December 2020

Direct micropuncture evidence that matrix extracellular phosphoglycoprotein inhibits proximal tubular phosphate reabsorption

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12 December 2020