Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease (Q24620476)

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English	Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease	scientific article

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scholarly article

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Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease (English)

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Alzheimer's disease

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based on heuristic

inferred from title

solute carrier family 1 member 2

1 reference

GOA release 2020-03-11

Solute carrier family 1 (glial high affinity glutamate transporter), member 2

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GOA release 2020-03-11

Cytochrome P450, family 46, subfamily a, polypeptide 1

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

Guilian Tian

1

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Qiongman Kong

2

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Liching Lai

3

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Abhik Ray-Chaudhury

4

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Chien-liang G Lin

5

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language of work or name

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publication date

May 2010

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Journal of Neurochemistry

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113

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4

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978-89

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3010752/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism

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7 April 2017

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

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7 April 2017

Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese

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7 April 2017

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

1 reference

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7 April 2017

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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7 April 2017

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

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7 April 2017

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

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27 September 2017

Lipid raft microdomains and neurotransmitter signalling

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27 September 2017

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

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27 September 2017

Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease

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27 September 2017

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

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27 September 2017

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

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27 September 2017

Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type

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27 September 2017

Association of CYP46 intron 2 polymorphism in Finnish Alzheimer's disease samples and a global scale summary

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30 May 2018

Changes in the cellular distribution of glutamine synthetase in Alzheimer's disease

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30 May 2018

Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease

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30 May 2018

Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?

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30 May 2018

Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

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30 May 2018

Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease

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30 May 2018

Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease

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30 May 2018

Sodium-dependent glutamate binding in senile dementia

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30 May 2018

Region-specific loss of glutamate innervation in Alzheimer's disease.

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30 May 2018

Regional changes in [3H]D-aspartate and [3H]TCP binding sites in Alzheimer's disease brains

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30 May 2018

Sodium dependent D-[3H]aspartate binding in cerebral cortex in patients with Alzheimer's and Parkinson's diseases

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30 May 2018

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

1 reference

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30 May 2018

Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression

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28 November 2018

Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease.

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28 November 2018

Translational Control of Glial Glutamate Transporter EAAT2 Expression

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28 November 2018

Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function.

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28 November 2018

Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease

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28 November 2018

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

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28 November 2018

Caveolin and GLT-1 gene expression is reciprocally regulated in primary astrocytes: association of GLT-1 with non-caveolar lipid rafts

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28 November 2018

Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function.

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28 November 2018

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

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28 November 2018

Human glioma cells and undifferentiated primary astrocytes that express aberrant EAAT2 mRNA inhibit normal EAAT2 protein expression and prevent cell death

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28 November 2018

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

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28 November 2018

A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release.

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28 November 2018

Glutamate Transporter Alterations in Alzheimer Disease Are Possibly Associated with Abnormal APP Expression

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28 November 2018

Brain glutamate transporter proteins form homomultimers

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28 November 2018

Variant forms of neuronal glutamate transporter sites in Alzheimer's disease cerebral cortex.

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28 November 2018

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

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Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease

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Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains

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10.1111/J.1471-4159.2010.06661.X

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PMC publication ID

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PubMed publication ID

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