Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase (Q24555183)

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A Egashira

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H Igarashi

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T Iwakuma

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Y Nakatsuru

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Y Tominaga

6

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H Kawate

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K Nakao

8

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K Nakamura

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F Ide

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S Kura

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Y Nakabeppu

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M Katsuki

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T Ishikawa

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M Sekiguchi

Proceedings of the National Academy of Sciences of the United States of America

15

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language of work or name

English

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publication date

25 September 2001

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published in

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volume

98

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issue

20

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page(s)

11456-61

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Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

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Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution

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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

7 April 2017

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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

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Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation

27 September 2017

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Organization and expression of the mouse MTH1 gene for preventing transversion mutation

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Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

30 May 2018

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Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization.

30 May 2018

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8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions

30 May 2018

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30 May 2018

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Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting.

28 November 2018

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Potential of Escherichia coli GTP cyclohydrolase II for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

28 November 2018

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Genetic background alters the spectrum of tumors that develop in p53-deficient mice

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Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

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Modification of DNA bases in mammalian chromatin by radiation-generated free radicals

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Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells

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Two nicking enzyme systems specific for mismatch-containing DNA in nuclear extracts from human cells

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Metabolic fate of oxidized guanine ribonucleotides in mammalian cells

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