Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells (Q24552563)

1

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D Kipling

2

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M Morris

3

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P Hepburn

4

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J Skinner

5

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A Bounacer

6

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F S Wyllie

7

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M Ivan

8

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J Bartek

9

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D Wynford-Thomas

10

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J A Bond

Molecular and Cellular Biology

11

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language of work or name

English

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publication date

August 2000

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published in

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volume

20

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issue

15

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page(s)

5690-9

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cites work

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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

7 April 2017

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras.

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Cellular senescence and cancer

27 September 2017

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Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)

27 September 2017

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Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts

27 September 2017

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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

27 September 2017

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

27 September 2017

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A reassessment of the telomere hypothesis of senescence

27 September 2017

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A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization

27 September 2017

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p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers

27 September 2017

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RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity

27 September 2017

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27 September 2017

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Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation

27 September 2017

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Dissociation of telomere dynamics from telomerase activity in human thyroid cancer cells.

27 September 2017

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Inactivation of p16 in human mammary epithelial cells by CpG island methylation

27 September 2017

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A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes

27 September 2017

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Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies

27 September 2017

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Overcoming cellular senescence in human cancer pathogenesis

27 September 2017

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

27 September 2017

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Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

27 September 2017

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Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

27 September 2017

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Expression of p27Kip1 in osteoblast-like cells during differentiation with parathyroid hormone

27 September 2017

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Aberrant p27kip1 expression in endocrine and other tumors

27 September 2017

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

27 September 2017

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

27 September 2017

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27 September 2017

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DNA damage and repair in telomeres: relation to aging

27 September 2017

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Telomerase activity in normal and malignant hematopoietic cells

27 September 2017

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Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

27 September 2017

1 reference

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Spontaneous de-differentiation correlates with extended lifespan in transformed thyroid epithelial cells: an epigenetic mechanism of tumour progression?

27 September 2017

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Presence of mutations in all three ras genes in human thyroid tumors

27 September 2017

1 reference

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Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells.

27 September 2017

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Differential patterns of cell cycle regulatory proteins expression in transgenic models of thyroid tumours

30 May 2018

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

30 May 2018

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Ras versus cyclin-dependent kinase inhibitors

30 May 2018

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Expression of p27kip1 and Ki-67 in benign and malignant thyroid tumors.

30 May 2018

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p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis

30 May 2018

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Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

30 May 2018

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Cyclin E-CDK2 is a regulator of p27Kip1.

30 May 2018

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Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells.

30 May 2018

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In vitro reconstruction of tumour initiation in a human epithelium.

30 May 2018

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Loss of dependence on IGF-1 for proliferation of human thyroid adenoma cells

30 May 2018

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Partial transformation of human thyroid epithelial cells by mutant Ha-ras oncogene

30 May 2018

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30 May 2018

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The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis.

28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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12 December 2020

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High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis

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12 December 2020

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

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12 December 2020

Downregulation of p27KIP1 and Ki67/Mib1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories

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12 December 2020

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12 December 2020

Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells

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12 December 2020

Abnormalities of the P16INK4A gene in thyroid cancer cell lines

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12 December 2020

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

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12 December 2020