LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation (Q24536102)

Ligand of numb-protein X 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Jing Nie

1

0 references

Melanie A McGill

2

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Matt Dermer

3

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Sascha E Dho

4

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Cheryl D Wolting

5

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C Jane McGlade

Numb is an endocytic protein

6

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language of work or name

English

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publication date

15 January 2002

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published in

The EMBO Journal

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volume

21

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issue

1-2

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page(s)

93-102

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cites work

1 reference

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Mouse numb is an essential gene involved in cortical neurogenesis

24 March 2017

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

24 March 2017

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The Mdm2 oncoprotein interacts with the cell fate regulator Numb

24 March 2017

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Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway

24 March 2017

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Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module

24 March 2017

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Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity

24 March 2017

1 reference

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Notch signaling: cell fate control and signal integration in development

24 March 2017

1 reference

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24 March 2017

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PDZ domains and the organization of supramolecular complexes

24 March 2017

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RING finger proteins: mediators of ubiquitin ligase activity

24 March 2017

1 reference

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The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

24 March 2017

1 reference

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

24 March 2017

1 reference

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The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX

24 March 2017

1 reference

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Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis

24 March 2017

1 reference

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The RING finger domain: a recent example of a sequence-structure family

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

24 March 2017

1 reference

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Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Origin of PDZ (DHR, GLGF) domains

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

24 March 2017

1 reference

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Does this have a familiar RING?

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Cell polarity: squaring the circle

7 April 2017

1 reference

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Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases

27 September 2017

1 reference

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Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Recognition specificity of individual EH domains of mammals and yeast

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Cell fate determination in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Numb antagonizes Notch signaling to specify sibling neuron cell fates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Multiple roles of mouse Numb in tuning developmental cell fates.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Segregation of myogenic lineages in Drosophila requires numb.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Asymmetric segregation of Numb and Prospero during cell division

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Origin and specification of type II sensory neurons in Drosophila.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125803

Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11782429

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

One ring to rule a superfamily of E3 ubiquitin ligases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11782429

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/EMBOJ/21.1.93

1 reference

1 reference

1 reference

PubMed publication ID

11782429

1 reference