ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts (Q24337520)

Three prime repair exonuclease 1

1 reference

ATR serine/threonine kinase

1 reference

MutSalpha complex binding

1 reference

MutS homolog 6

1 reference

Three prime repair exonuclease 1

1 reference

MutS homolog 2

1 reference

MutL homolog 1

1 reference

Mismatch repair endonuclease PMS2

1 reference

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

author name string

Ken-ichi Yoshioka

series ordinal

1

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Yoshiko Yoshioka

series ordinal

2

0 references

Peggy Hsieh

series ordinal

3

0 references

language of work or name

English

0 references

publication date

19 May 2006

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published in

Molecular Cell

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volume

22

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issue

4

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page(s)

501-10

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2

19 March 2017

1 reference

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MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Mechanism of 5'-directed excision in human mismatch repair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

The mismatch repair system is required for S-phase checkpoint activation

19 March 2017

1 reference

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

19 March 2017

1 reference

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Proteome survey reveals modularity of the yeast cell machinery

19 March 2017

1 reference

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SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

19 March 2017

1 reference

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19 March 2017

1 reference

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An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

19 March 2017

1 reference

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ATR and ATRIP: partners in checkpoint signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility

19 March 2017

1 reference

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Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

TopBP1 activates the ATR-ATRIP complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Mismatch repair and DNA damage signalling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Regulation of DNA replication by ATR: signaling in response to DNA intermediates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

27 September 2017

1 reference

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Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.

27 September 2017

1 reference

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A novel protein activity mediates DNA binding of an ATR-ATRIP complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Msh2 deficiency does not contribute to cisplatin resistance in mouse embryonic stem cells

27 September 2017

1 reference

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Mismatch repair-dependent transcriptome changes in human cells treated with the methylating agent N-methyl-n'-nitro-N-nitrosoguanidine.

27 September 2017

1 reference

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DNA mismatch repair: molecular mechanisms and biological function

27 September 2017

1 reference

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RecQ helicases: suppressors of tumorigenesis and premature aging.

27 September 2017

1 reference

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Methylation-induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1

27 September 2017

1 reference

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Contribution of human mlh1 and pms2 ATPase activities to DNA mismatch repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

The effect of O6-methylguanine DNA adducts on the adenosine nucleotide switch functions of hMSH2-hMSH6 and hMSH2-hMSH3.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

The role of mismatch repair in DNA damage-induced apoptosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Methyl-directed repair of DNA base-pair mismatches in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Novel dominant mutations in Saccharomyces cerevisiae MSH6.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Kinetics of extension of O6-methylguanine paired with cytosine or thymine in defined oligonucleotide sequences

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423943

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint

29 November 2018

1 reference

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Mechanisms of tolerance to DNA damaging therapeutic drugs

29 November 2018

1 reference

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DNA replication arrest and tolerance to DNA methylation damage.

29 November 2018

1 reference

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An evaluation of the double thymidine block for synchronizing mammalian cells at the G1-S border*1

29 November 2018

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https://pubmed.ncbi.nlm.nih.gov/16713580

12 December 2020

Heteroduplex repair in extracts of human HeLa cells

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https://pubmed.ncbi.nlm.nih.gov/16713580

12 December 2020

Signaling mismatch repair in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16713580

12 December 2020

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16713580

12 December 2020

10.1016/J.MOLCEL.2006.04.023

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

16713580

1 reference