The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins (Q24324729)

positive regulation of GTPase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Francis Collins

7

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Douglas A Marchuk

1 reference

ORCID Public Data File 2021

author name string

R Ballester

1

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D Marchuk

2

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M Boguski

3

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A Saulino

4

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R Letcher

5

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M Wigler

Autoradiography using storage phosphor technology

6

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language of work or name

English

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publication date

16 November 1990

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published in

Cell

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volume

63

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issue

4

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page(s)

851-9

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cites work

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A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

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Weights for data related by a tree

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[12] One-step gene disruption in yeast

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Production of single-stranded plasmid DNA

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Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

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In yeast, RAS proteins are controlling elements of adenylate cyclase.

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The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway

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Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene

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Genetic analysis of mammalian GAP expressed in yeast.

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The neurofibromatosis type 1 gene encodes a protein related to GAP

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S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein.

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ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

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Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

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A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

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Basic local alignment search tool

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Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

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Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

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The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product.

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Suppression of c-ras transformation by GTPase-activating protein

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Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway.

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Predictive motifs derived from cytosine methyltransferases

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Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients

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Two NF1 translocations map within a 600-kilobase segment of 17q11.2.

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Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

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Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17

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CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae

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Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

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IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein.

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Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae

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IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae

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