Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models (Q24315670)

GOA release 2020-03-11

1 reference

1 reference

24

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Karin Giller

16

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Christian Griesinger

23

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Nasrollah Rezaei-Ghaleh

5

Nasrollah Rezaei-Ghaleh

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Felipe Opazo

Felipe Opazo

4

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Henrike Heise

Henrike Heise

10

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Gerhard H Braus

Gerhard H Braus

15

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Jörg B. Schulz

Jörg B Schulz

22

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Marc Baldus

Marc Baldus

19

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Alf Herzig

18

Alf Herzig

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Herbert Jäckle

20

Herbert Jäckle

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Madhu Babu Gajula Balija

2

Madhu Babu Gajula Balija

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Sebastian Kügler

3

Sebastian Kügler

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Grit Taschenberger

8

Grit Taschenberger

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author name string

Damla Pinar Karpinar

1

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Nora Wender

6

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Hai-Young Kim

7

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Björn H Falkenburger

9

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Ashutosh Kumar

11

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Dietmar Riedel

12

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Lars Fichtner

13

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Aaron Voigt

14

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Stefan Becker

17

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Stefan Eimer

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

21

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language of work or name

English

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publication date

21 October 2009

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published in

The EMBO Journal

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volume

28

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issue

20

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page(s)

3256-68

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cites work

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

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C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

19 March 2017

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A specific amyloid-beta protein assembly in the brain impairs memory

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alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases

7 April 2017

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

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A Drosophila model of Parkinson's disease

7 April 2017

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

7 April 2017

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Structural rearrangements of membrane proteins probed by water-edited solid-state NMR spectroscopy.

7 April 2017

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The fold of alpha-synuclein fibrils

27 September 2017

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Accumulation and clearance of alpha-synuclein aggregates demonstrated by time-lapse imaging

27 September 2017

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Animal models of Parkinson's disease progression

27 September 2017

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Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

27 September 2017

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The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

27 September 2017

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Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils

27 September 2017

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Cell systems and the toxic mechanism(s) of alpha-synuclein

27 September 2017

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Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

27 September 2017

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Band-selective 13C homonuclear 3D spectroscopy for solid proteins at high field with rotor-synchronized soft pulses

27 September 2017

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Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR.

27 September 2017

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Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

27 September 2017

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The E46K mutation in alpha-synuclein increases amyloid fibril formation.

27 September 2017

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Alpha-synuclein: normal function and role in neurodegenerative diseases.

27 September 2017

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The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration

27 September 2017

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Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

27 September 2017

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Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

27 September 2017

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

27 September 2017

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

27 September 2017

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

27 September 2017

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

27 September 2017

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On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster

27 September 2017

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The structure of amyloid fibrils by electron microscopy and X-ray diffraction

27 September 2017

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Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein.

30 May 2018

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Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.

29 November 2018

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The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states

29 November 2018

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Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

29 November 2018

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Cysteine misincorporation in bacterially expressed human alpha-synuclein

29 November 2018

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Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans

29 November 2018

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Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

29 November 2018

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Yeast cells provide insight into alpha-synuclein biology and pathobiology

29 November 2018

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Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

29 November 2018

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Dependence of alpha-synuclein aggregate morphology on solution conditions

29 November 2018

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Conformational properties of alpha-synuclein in its free and lipid-associated states

29 November 2018

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

29 November 2018

1 reference

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Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

29 November 2018

1 reference

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An Improved Broadband Decoupling Sequence for Liquid Crystals and Solids

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19745811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Protein solid-state NMR resonance assignments from (13C,13C) correlation spectroscopy

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.257

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2009.257

1 reference

1 reference

1 reference

PubMed publication ID

19745811

1 reference