Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity (Q24306113)

positive regulation of transcription by RNA polymerase II

GOA release 2020-03-11

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POU domain, class 4, transcription factor 3

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Sally J Dawson

7

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Matthew Holley

object named as

Matthew Holley

6

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Karen Avraham

object named as

Karen B Avraham

5

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author name string

R Lee Clough

1

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Richa Sud

2

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Noa Davis-Silberman

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Ronna Hertzano

Biochemical and Biophysical Research Communications

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language of work or name

English

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publication date

5 November 2004

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published in

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volume

324

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issue

1

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page(s)

372-81

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cites work

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Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

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Multiple promoters direct tissue-specific expression of the rat BDNF gene

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Complementary roles of BDNF and NT-3 in vestibular and auditory development

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POU-domain proteins: structure and function of developmental regulators

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The role of neurotrophic factors in regulating the development of inner ear innervation

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Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter

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Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors

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Effects of a hair cell transcription factor, Brn-3.1, gene deletion on homozygous and heterozygous mouse cochleas in adulthood and aging

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Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development

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Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons

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Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia.

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Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling

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Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development

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A Single Amino Acid Change Converts an Inhibitory Transcription Factor into an Activator

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Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice

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Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene

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A single residue within the homeodomain of the Brn-3 POU family transcription factors determines whether they activate or repress the SNAP-25 promoter

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The Brn-3c transcription factor contains a neuronal-specific activation domain

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Functional role of position 22 in the homeodomain of Brn-3 transcription factors

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Novel cell lines display properties of nociceptive sensory neurons.

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Auditory hair cell precursors immortalized from the mammalian inner ear.

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POU domain family values: flexibility, partnerships, and developmental codes

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Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development

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Two promoters direct transcription of the mouse NT-3 gene

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Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans

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POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution

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The DFNA15 deafness mutation affects POU4F3 protein stability, localization, and transcriptional activity

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Mouse nerve growth factor gene: structure and expression

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BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development.

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The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons

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