Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. (Q24304921)

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16 January 2020

title

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis (English)

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16 January 2020

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16 January 2020

Nozomi Sugimoto

2

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16 January 2020

Vassilis Roukos

3

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16 January 2020

Masatoshi Fujita

10

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16 January 2020

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Zoi Lygerou

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16 January 2020

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Chikashi Obuse

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16 January 2020

author name string

Yohsuke Nakanishi

4

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16 January 2020

Masafumi Saijo

5

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16 January 2020

Toshiki Tsurimoto

7

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16 January 2020

Keiichi I Nakayama

8

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16 January 2020

Keiko Nakayama

9

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16 January 2020

Takeharu Nishimoto

12

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language of work or name

English

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publication date

16 February 2006

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16 January 2020

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16 January 2020

volume

25

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16 January 2020

issue

5

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16 January 2020

page(s)

1126-1136

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Preventing re-replication of chromosomal DNA.

16 January 2020

cites work

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Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

19 March 2017

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Loss of Geminin induces rereplication in the presence of functional p53

19 March 2017

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Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

19 March 2017

1 reference

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The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

19 March 2017

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Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

19 March 2017

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Geminin, an inhibitor of DNA replication, is degraded during mitosis

19 March 2017

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The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

19 March 2017

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A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex

19 March 2017

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G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

19 March 2017

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Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase

19 March 2017

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DNA replication in eukaryotic cells

19 March 2017

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The replicative regulator protein geminin on chromatin in the HeLa cell cycle

19 March 2017

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Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

19 March 2017

1 reference

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Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

19 March 2017

1 reference

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The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

19 March 2017

1 reference

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The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase

19 March 2017

1 reference

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Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

19 March 2017

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The Cdt1 protein is required to license DNA for replication in fission yeast

19 March 2017

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In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP

19 March 2017

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G1 phase progression: cycling on cue

19 March 2017

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Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase

7 April 2017

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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

27 September 2017

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Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.

27 September 2017

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Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage

27 September 2017

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APC/C and SCF: controlling each other and the cell cycle

27 September 2017

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Regulation of early events in chromosome replication

27 September 2017

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DNA replication licensing

27 September 2017

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Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines

27 September 2017

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Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex

27 September 2017

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A p53-dependent checkpoint pathway prevents rereplication

27 September 2017

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Replication licensing--defining the proliferative state?

27 September 2017

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

27 September 2017

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Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

27 September 2017

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Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

27 September 2017

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Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.

27 September 2017

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Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress

27 September 2017

1 reference

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Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development

29 November 2018

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Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs

29 November 2018

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Protein associations in DnaA-ATP hydrolysis mediated by the Hda-replicase clamp complex

29 November 2018

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Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.

29 November 2018

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Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region

29 November 2018

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Skp2-mediated degradation of p27 regulates progression into mitosis

29 November 2018

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CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing

29 November 2018

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The initiator function of DnaA protein is negatively regulated by the sliding clamp of the E. coli chromosomal replicase.

29 November 2018

1 reference

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Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16482215

12 December 2020

Ordering S phase and M phase in the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16482215

12 December 2020

p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/16482215

12 December 2020

Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16482215

12 December 2020

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/16482215

12 December 2020

Identifiers

DOI

10.1038/SJ.EMBOJ.7601002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16482215%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

16 January 2020

4744193

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16482215%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

16482215

1 reference