USP10 regulates p53 localization and stability by deubiquitinating p53 (Q24296967)

Ubiquitin specific peptidase 7

1 reference

Ubiquitin specific peptidase 10

1 reference

tumor protein p53

1 reference

author name string

Jian Yuan

1

0 references

Kuntian Luo

2

0 references

Lizhi Zhang

3

0 references

John C Cheville

4

0 references

Zhenkun Lou

Molecular recognition of p53 and MDM2 by USP7/HAUSP

5

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language of work or name

English

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publication date

5 February 2010

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published in

Cell

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volume

140

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issue

3

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page(s)

384-96

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cites work

1 reference

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Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway

19 March 2017

1 reference

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Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

19 March 2017

1 reference

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

19 March 2017

1 reference

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

19 March 2017

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Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

19 March 2017

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

19 March 2017

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Mdm2 promotes the rapid degradation of p53

19 March 2017

1 reference

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A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

19 March 2017

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19 March 2017

Surfing the p53 network

1 reference

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Tumour suppression: disruption of HAUSP gene stabilizes p53

6 April 2017

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A dynamic role of HAUSP in the p53-Mdm2 pathway

19 March 2017

1 reference

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Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease

19 March 2017

1 reference

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

19 March 2017

1 reference

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

19 March 2017

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

19 March 2017

1 reference

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

19 March 2017

1 reference

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Transcriptional control of human p53-regulated genes

19 March 2017

1 reference

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p53 ubiquitination: Mdm2 and beyond

7 April 2017

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

7 April 2017

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Cell cycle checkpoint signaling through the ATM and ATR kinases

7 April 2017

1 reference

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Post-translational modifications and activation of p53 by genotoxic stresses

7 April 2017

1 reference

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Cancer. p53, guardian of the genome

7 April 2017

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The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

7 April 2017

1 reference

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The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

27 September 2017

1 reference

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The role of ubiquitination in the direct mitochondrial death program of p53.

27 September 2017

1 reference

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Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics

27 September 2017

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Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM).

27 September 2017

1 reference

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Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

27 September 2017

1 reference

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

27 September 2017

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

27 September 2017

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Parc: a cytoplasmic anchor for p53.

27 September 2017

1 reference

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Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820153

C-terminal ubiquitination of p53 contributes to nuclear export

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820153

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820153

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820153

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820153

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820153

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

27 September 2017

1 reference

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Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

27 September 2017

1 reference

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820153

The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820153

The MDM2 RING-finger domain is required to promote p53 nuclear export

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820153

p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20096447

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Induction of p53-independent apoptosis by simian virus 40 small t antigen

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CELL.2009.12.032

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2009.12.032

1 reference

1 reference

1 reference

PubMed publication ID

20096447

1 reference