MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells (Q24290823)

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H Eguchi

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S Nakashima

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A Suzuki

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M Toi

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Y Nozawa

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S Hayashi

Biochemical and Biophysical Research Communications

9

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language of work or name

English

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publication date

16 February 2001

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published in

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volume

281

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issue

1

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page(s)

259-65

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cites work

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The tumor suppressor p53 is a negative regulator of estrogen receptor signaling pathways

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The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

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The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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Overexpression of MDM2 in MCF-7 promotes both growth advantage and p53 accumulation in response to estradiol.

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