Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors (Q24290397)

cholesterol metabolic process

GOA release 2020-03-11

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GOA release 2020-03-11

6

J Auwerx

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author name string

T T Lu

1

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M Makishima

2

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J J Repa

3

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K Schoonjans

4

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T A Kerr

5

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D J Mangelsdorf

Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences

7

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language of work or name

English

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publication date

September 2000

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published in

Molecular Cell

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volume

6

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issue

3

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page(s)

507-15

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cites work

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Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1

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Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12alpha -hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription

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Identification of a nuclear receptor that is activated by farnesol metabolites

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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Steroidogenic factor-1: its role in endocrine organ development and differentiation

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Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.

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DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

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The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta

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Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols

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The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

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Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers

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Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

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Identification of a nuclear receptor for bile acids

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Nuclear receptor that identifies a novel retinoic acid response pathway

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Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression

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CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene

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The roles of steroidogenic factor 1 in endocrine development and function

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Bile acids: natural ligands for an orphan nuclear receptor

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The LXRs: a new class of oxysterol receptors

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

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The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

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Nuclear orphan receptors control cholesterol catabolism.

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Bile acid biosynthesis

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An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

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Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

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Regulation of sterol 12alpha-hydroxylase and cholic acid biosynthesis in the rat.

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Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

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LXR, a nuclear receptor that defines a distinct retinoid response pathway

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