Functional Selectivity and Classical Concepts of Quantitative Pharmacology (Q22242288)

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25 December 2019

review article

1 reference

title

Functional selectivity and classical concepts of quantitative pharmacology (English)

1 reference

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25 December 2019

1 reference

1

Jonathan D Urban

Jonathan D

Urban

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25 December 2019

6

Harel Weinstein

Harel

Weinstein

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25 December 2019

7

Jonathan A Javitch

Jonathan A

Javitch

1 reference

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25 December 2019

9

Arthur Christopoulos

Arthur

Christopoulos

1 reference

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25 December 2019

10

Patrick M Sexton

Patrick M

Sexton

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25 December 2019

12

Michael Spedding

Michael

Spedding

1 reference

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25 December 2019

13

Richard B Mailman

Richard B

Mailman

1 reference

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25 December 2019

3

Mark von Zastrow

Mark

von Zastrow

1 reference

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25 December 2019

5

Brian Kobilka

Brian

Kobilka

1 reference

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25 December 2019

William P Clarke

2

William P

Clarke

1 reference

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25 December 2019

David E Nichols

series ordinal

4

author given names

David E

author last names

Nichols

1 reference

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25 December 2019

Bryan L Roth

series ordinal

8

author given names

Bryan L

author last names

Roth

1 reference

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25 December 2019

Keith J Miller

series ordinal

11

author given names

Keith J

author last names

Miller

1 reference

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25 December 2019

language of work or name

English

0 references

publication date

27 June 2006

1 reference

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Journal of Pharmacology and Experimental Therapeutics

25 December 2019

published in

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25 December 2019

volume

320

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25 December 2019

issue

1

1 reference

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25 December 2019

page(s)

1-13

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Therapeutic targeting of alpha 4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit?

25 December 2019

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Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein

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7 January 2021

Regulation of 5-HT(2A) receptor mRNA levels and binding sites in rat frontal cortex by the agonist DOI and the antagonist mianserin

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7 January 2021

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7 January 2021

Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization

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7 January 2021

Dynamic mechanisms of non-classical antagonism by competitive AT(1) receptor antagonists

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7 January 2021

The elusive nature of intrinsic efficacy

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7 January 2021

Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo

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7 January 2021

Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists

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7 January 2021

Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes

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7 January 2021

Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

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7 January 2021

Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligands

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Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells

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7 January 2021

Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands

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7 January 2021

trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist

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7 January 2021

A New Concept on the Mode of Interaction of Narcotic Analgesics with Receptors

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Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping

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Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

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Principles for modulation of the nuclear receptor superfamily

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A pathophysiological paradigm for the therapy of psychiatric disease

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New concepts in drug discovery: collateral efficacy and permissive antagonism

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Finding new tricks for old drugs: an efficient route for public-sector drug discovery

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Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1alpha.

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Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.

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RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity

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7 January 2021

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.

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Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways.

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A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases

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Nephrogenic syndrome of inappropriate antidiuresis

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Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease

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Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

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Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis

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A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation

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7 January 2021

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo

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Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

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7 January 2021

Morphine-activated opioid receptors elude desensitization by beta-arrestin

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7 January 2021

Morphine activates opioid receptors without causing their rapid internalization

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Mu opioid receptor phosphorylation, desensitization, and ligand efficacy

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C5a receptor activation. Genetic identification of critical residues in four transmembrane helices

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Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

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The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis

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7 January 2021

Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.

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7 January 2021

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

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7 January 2021

Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50).

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7 January 2021

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

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7 January 2021

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

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7 January 2021

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

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7 January 2021

Differences in conformational properties of the second intracellular loop (IL2) in 5HT(2C) receptors modified by RNA editing can account for G protein coupling efficiency

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7 January 2021

Differential phospholipase C activation by phenylalkylamine serotonin 5-HT 2A receptor agonists

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Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism

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7 January 2021

Pleiotropic behavior of 5-HT2A and 5-HT2C receptor agonists

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Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors

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Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves

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Mechanisms of ligand-induced desensitization of the 5-hydroxytryptamine(2A) receptor

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Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase

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Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs

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Rapid desensitization of the serotonin(2C) receptor system: effector pathway and agonist dependence

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7 January 2021

Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists

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7 January 2021

Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus

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7 January 2021

Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking

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Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy.

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Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies

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Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states

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G protein-coupled receptor allosterism and complexing

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The human polyomavirus, JCV, uses serotonin receptors to infect cells

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7 January 2021

Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors

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7 January 2021

Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens.

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7 January 2021

Chronic treatment with dopamine receptor antagonists: behavioral and pharmacologic effects on D1 and D2 dopamine receptors

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7 January 2021

mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization.

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Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex

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Dopamine partial agonists: a new class of antipsychotic

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Partial dopamine agonists and dopaminergic stabilizers, in the treatment of psychosis

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Dopamine system stabilizers, aripiprazole, and the next generation of antipsychotics, part 1, "Goldilocks" actions at dopamine receptors.

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7 January 2021

Dopamine system stabilizers, aripiprazole, and the next generation of antipsychotics, part 2: illustrating their mechanism of action.

1 reference

https://api.crossref.org/works/10.1124%2FJPET.106.104463

7 January 2021

Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/JPET.106.104463

Identifiers

DOI

10.1124/JPET.106.104463

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803859%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017