A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho (Q22008793)

positive regulation of transcription, DNA-templated

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

S Fukuhara

1

S

Fukuhara

1 reference

7 February 2023

C Murga

2

C

Murga

1 reference

7 February 2023

M Zohar

3

M

Zohar

1 reference

7 February 2023

T Igishi

4

T

Igishi

1 reference

7 February 2023

J S Gutkind

5

J S

Gutkind

1 reference

Journal of Biological Chemistry

7 February 2023

language of work or name

English

0 references

publication date

26 February 1999

0 references

published in

0 references

volume

274

0 references

issue

9

0 references

page(s)

5868-79

0 references

cites work

The GTPase superfamily: conserved structure and molecular mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Proteins regulating Ras and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

GAPs for rho-related GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

How receptor tyrosine kinases activate Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Interactions between Ras and Raf: key regulatory proteins in cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Rho effectors and reorganization of actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The small GTPase Rho: cellular functions and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Rho GTPases and signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Molecular cloning and expression analysis of rat Rgs12 and Rgs14

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The pleckstrin homology domain: an intriguing multifunctional protein module

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Protein-protein interactions: PDZ domain networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Microinjection of recombinant p21rho induces rapid changes in cell morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The Drosophila gastrulation gene concertina encodes a G alpha-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The Son of sevenless Gene Product: a Putative Activator of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The PH domain: a common piece in the structural patchwork of signalling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Mammalian RGS proteins: barbarians at the gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Signal transduction by G proteins: 1994 edition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Signaling by the G12 class of G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

G12 requirement for thrombin-stimulated gene expression and DNA synthesis in 1321N1 astrocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

inferred from DOI database lookup

7 January 2021

based on heuristic

The MAPK signaling cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.9.5868

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1074/JBC.274.9.5868

0 references