Paired-like homeodomain transcription factor 1 (Q21989886)

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mammalian protein found in Mus musculus

homeobox protein PITX1
homeobox protein P-OTX
Pitx1
pituitary homeobox 1
hindlimb-expressed homeobox protein backfoot
pituitary OTX-related factor

Language	Label	Description	Also known as
English	Paired-like homeodomain transcription factor 1	mammalian protein found in Mus musculus	homeobox protein PITX1 homeobox protein P-OTX Pitx1 pituitary homeobox 1 hindlimb-expressed homeobox protein backfoot pituitary OTX-related factor

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70314

Homeobox protein Pitx/unc30

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70314

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

OAR domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

1 reference

16 July 2018

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method or standard

2 references

16 July 2018

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

sequence-specific DNA binding

determination method or standard

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

DNA-binding transcription factor activity

determination method or standard

protein binding

determination method or standard

1 reference

14 February 2019

A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

2 references

14 February 2019

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method or standard

4 references

10 September 2018

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

7 November 2018

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

determination method or standard

1 reference

14 February 2019

Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

transcription regulator complex

determination method or standard

1 reference

14 February 2019

A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

determination method or standard

4 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

16 July 2018

Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

determination method or standard

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

biological process

embryonic hindlimb morphogenesis

determination method or standard

2 references

14 February 2019

Pitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

skeletal system development

determination method or standard

1 reference

14 February 2019

Hindlimb patterning and mandible development require the Ptx1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

multicellular organism development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

1 reference

14 February 2019

Identification of PITX1 as a TERT suppressor gene located on human chromosome 5

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

myoblast fate commitment

determination method or standard

1 reference

14 February 2019

Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

pituitary gland development

determination method or standard

1 reference

14 February 2019

Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

branchiomeric skeletal muscle development

determination method or standard

1 reference

14 February 2019

Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

cartilage development

determination method or standard

1 reference

14 February 2019

Hindlimb patterning and mandible development require the Ptx1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

hindlimb morphogenesis

determination method or standard

4 references

14 February 2019

Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Hindlimb patterning and mandible development require the Ptx1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

3 references

14 February 2019

RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

14 February 2019

A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

transcription by RNA polymerase II

determination method or standard

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70314&geneProductId=UniProtKB:P70314

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

anatomical structure morphogenesis

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70314

determination method or standard

Homeobox domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70314

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70314

Homeobox, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70314

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000021968

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000021968

ENSMUSP00000134609

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000134609

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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