Neurofilament, light polypeptide (Q21987272)

http://www.ebi.ac.uk/interpro/protein/P08551

Intermediate filament head, DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Intermediate filament, rod domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Intermediate filament protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein-macromolecule adaptor activity

1 reference

14 February 2019

The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

structural molecule activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

1 reference

14 February 2019

structural constituent of cytoskeleton

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

protein binding

5 references

14 February 2019

Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

structural constituent of postsynaptic intermediate filament cytoskeleton

1 reference

14 February 2019

Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

cell component

cytoplasm

1 reference

14 February 2019

The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

neurofilament

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

The cytoskeleton of the myenteric neurons during murine embryonic life

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

In vitro assembly properties of mutant and chimeric intermediate filament proteins: insight into the function of sequences in the rod and end domains of IF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Expression of catenins during mouse embryonic development and in adult tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

myelin sheath

1 reference

24 April 2018

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08551&geneProductId=UniProtKB:P08551

axon

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Expression of catenins during mouse embryonic development and in adult tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

intermediate filament

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

14 February 2019

Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

axon cytoplasm

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

neuron projection

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

neuromuscular junction

myelin sheath

HDA

1 reference

14 February 2019

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

Schaffer collateral - CA1 synapse

HDA

1 reference

14 February 2019

Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

cholinergic synapse

postsynaptic intermediate filament cytoskeleton

1 reference

14 February 2019

Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

presynaptic intermediate filament cytoskeleton

1 reference

14 February 2019

Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

negative regulation of neuron apoptotic process

biological process

2 references

14 February 2019

Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

intermediate filament organization

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

ISO

14 February 2019

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

neuron projection morphogenesis

1 reference

14 February 2019

Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

intermediate filament bundle assembly

2 references

14 February 2019

Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

neuromuscular process controlling balance

1 reference

14 February 2019

Mice with the deleted neurofilament of low molecular weight (Nefl) gene: 2. Effects on motor functions and spatial orientation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

response to corticosterone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

response to peptide hormone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

response to organic substance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

positive regulation of axonogenesis

1 reference

14 February 2019

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

regulation of axon diameter

peripheral nervous system axon regeneration

1 reference

14 February 2019

Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

locomotion

1 reference

14 February 2019

Late onset of motor neurons in mice overexpressing wild-type peripherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

response to acrylamide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

spinal cord development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

cerebral cortex development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

neurofilament cytoskeleton organization

Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Mice with targeted disruption of neurofilament light subunit display formation of protein aggregation in motoneurons and downregulation of complement receptor type 3 alpha subunit in microglia in the spinal cord at their earlier age: a possible feat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Neurofilament transport in vivo minimally requires hetero-oligomer formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Late onset of motor neurons in mice overexpressing wild-type peripherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

14 February 2019

No requirement of alpha-internexin for nervous system development and for radial growth of axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

hippocampus development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

response to toxic substance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

microtubule cytoskeleton organization

1 reference

14 February 2019

Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

axon development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

1 reference

14 February 2019

synapse maturation

postsynaptic intermediate filament cytoskeleton organization

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08551

Intermediate filament protein, conserved site

has part(s)

1 reference

http://www.ebi.ac.uk/interpro/protein/P08551

Intermediate filament head, DNA-binding domain

1 reference

http://www.ebi.ac.uk/interpro/protein/P08551

Intermediate filament, rod domain

1 reference