Smoothened, frizzled class receptor (Q21986823)

http://www.ebi.ac.uk/interpro/protein/P56726

Frizzled cysteine-rich domain superfamily

1 reference

stated in

http://www.ebi.ac.uk/interpro/protein/P56726

membrane protein

1 reference

inferred from GOA cell component → membrane

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

Frizzled domain, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

transmembrane signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

Wnt-activated receptor activity

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

G protein-coupled receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

endocytic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

11 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Vertebrate Smoothened functions at the primary cilium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

The hedgehog receptor patched is involved in cholesterol transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

integral component of membrane

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

dendritic growth cone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

The hedgehog receptor patched is involved in cholesterol transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

13 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Vertebrate Smoothened functions at the primary cilium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

anterior/posterior pattern specification

biological process

1 reference

8 April 2019

Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of neuroblast proliferation

1 reference

8 April 2019

alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

epithelial-mesenchymal cell signaling

1 reference

8 April 2019

Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

left/right axis specification

1 reference

8 April 2019

A phenotype-based screen for embryonic lethal mutations in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of gene expression

digestive tract development

2 references

1 reference

8 April 2019

Sox17 regulates organ lineage segregation of ventral foregut progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

negative regulation of hair follicle development

1 reference

8 April 2019

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of cell population proliferation

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of smoothened signaling pathway

1 reference

21 June 2018

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

regulation of stem cell population maintenance

1 reference

8 April 2019

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of transcription by RNA polymerase II

hair follicle morphogenesis

2 references

1 reference

8 April 2019

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function

pancreas morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

mesenchymal to epithelial transition involved in metanephric renal vesicle formation

1 reference

8 April 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

embryonic organ development

1 reference

8 April 2019

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

homeostasis of number of cells within a tissue

1 reference

8 April 2019

Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

mammary gland epithelial cell differentiation

IDA

1 reference

8 April 2019

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

negative regulation of apoptotic process

1 reference

8 April 2019

Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

8 April 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

renal system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

forebrain morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

cell surface receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

dentate gyrus development

1 reference

8 April 2019

Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

pattern specification process

1 reference

8 April 2019

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

smoothened signaling pathway involved in ventral spinal cord patterning

3 references

8 April 2019

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

protein stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

cell fate specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

odontogenesis of dentin-containing tooth

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of mesenchymal cell proliferation

1 reference

8 April 2019

Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

negative regulation of epithelial cell differentiation

1 reference

8 April 2019

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

negative regulation of gene expression

1 reference

8 April 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

central nervous system neuron differentiation

1 reference

8 April 2019

Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

atrial septum morphogenesis

1 reference

8 April 2019

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

cerebellar cortex morphogenesis

1 reference

8 April 2019

The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

type B pancreatic cell development

1 reference

8 April 2019

Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

regulation of heart morphogenesis

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

cellular response to cholesterol

1 reference

8 April 2019

The hedgehog receptor patched is involved in cholesterol transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

dorsal/ventral pattern formation

skeletal muscle fiber development

1 reference

8 April 2019

Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

1 reference

8 April 2019

The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

determination of left/right asymmetry in lateral mesoderm

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

neural crest cell migration

1 reference

8 April 2019

Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of multicellular organism growth

1 reference

8 April 2019

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of organ growth

1 reference

8 April 2019

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

ventral midline determination

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

cerebral cortex development

1 reference

8 April 2019

Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

osteoblast differentiation

1 reference

8 April 2019

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of hh target transcription factor activity

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

central nervous system development

1 reference

21 June 2018

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

regulation of gene expression

1 reference

8 April 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

8 April 2019

Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of protein import into nucleus

1 reference

8 April 2019

Hedgehog-regulated localization of Vax2 controls eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

in utero embryonic development

1 reference

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

dorsal/ventral neural tube patterning

1 reference

8 April 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

protein localization to nucleus

1 reference

8 April 2019

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

negative regulation of DNA binding

smoothened signaling pathway

10 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Vertebrate Smoothened functions at the primary cilium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

Hedgehog-regulated localization of Vax2 controls eye development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

multicellular organism growth

non-canonical Wnt signaling pathway

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

canonical Wnt signaling pathway

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

negative regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

axon extension involved in axon guidance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

commissural neuron axon guidance

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

negative regulation of neuron death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of vascular associated smooth muscle cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

positive regulation of neural precursor cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

Wnt signaling pathway

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

smoothened signaling pathway

11 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Vertebrate Smoothened functions at the primary cilium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Hedgehog-regulated localization of Vax2 controls eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

central nervous system development

positive regulation of smoothened signaling pathway

positive regulation of gene expression

3 references

1 January 2018

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

1 January 2018

Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

positive regulation of cell migration

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726

positive regulation of gene expression

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726

1 reference

http://www.ebi.ac.uk/interpro/protein/P56726

GPCR, family 2-like

1 reference

stated in

http://www.ebi.ac.uk/interpro/protein/P56726

Frizzled/Smoothened, transmembrane domain

1 reference

stated in