PTK2 protein tyrosine kinase 2 (Q21984735)

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mammalian protein found in Mus musculus
  • focal adhesion kinase-related nonkinase
  • Ptk2
  • FRNK
  • protein-tyrosine kinase 2
  • p125FAK
  • focal ashension kinase 1
  • FADK 1
  • focal adhesion kinase 1
  • pp125FAK
edit
Language Label Description Also known as
English
PTK2 protein tyrosine kinase 2
mammalian protein found in Mus musculus
  • focal adhesion kinase-related nonkinase
  • Ptk2
  • FRNK
  • protein-tyrosine kinase 2
  • p125FAK
  • focal ashension kinase 1
  • FADK 1
  • focal adhesion kinase 1
  • pp125FAK

Statements

part of
molecular function
protein binding
determination method
IPI
15 references
retrieved
9 May 2019
stated in
Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Phosphoinositide 3-kinase p85beta regulates invadopodium formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
retrieved
9 May 2019
stated in
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IPI
protein tyrosine kinase activity
determination method
IEA
ISS
ISO
EXP
IDA
TAS
8 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
TAS
retrieved
5 June 2018
stated in
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
ISS
retrieved
5 June 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
ISO
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
5 June 2018
stated in
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
5 June 2018
stated in
Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
EXP
retrieved
5 June 2018
stated in
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
EXP
non-membrane spanning protein tyrosine kinase activity
determination method
IEA
IMP
ISO
ISS
6 references
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
ISS
retrieved
5 June 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
ISO
retrieved
5 June 2018
stated in
Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IMP
retrieved
5 June 2018
stated in
Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IMP
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IEA
protein tyrosine kinase activity
determination method
EXP
IDA
IEA
ISO
TAS
7 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
9 May 2019
stated in
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
9 May 2019
stated in
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
EXP
retrieved
9 May 2019
stated in
Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
EXP
non-membrane spanning protein tyrosine kinase activity
determination method
IBA
IEA
IMP
ISO
ISS
7 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
ISO
retrieved
9 May 2019
stated in
Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IMP
retrieved
9 May 2019
stated in
Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IBA
cell component
focal adhesion
determination method
IDA
IEA
ISO
9 references
retrieved
5 June 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
ISO
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
5 June 2018
stated in
Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
5 June 2018
stated in
Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
5 June 2018
stated in
Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
5 June 2018
stated in
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
5 June 2018
stated in
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34152&geneProductId=UniProtKB:P34152
determination method
IDA
focal adhesion
determination method
IBA
IDA
IEA
ISO
10 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
9 May 2019
stated in
Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
9 May 2019
stated in
Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
9 May 2019
stated in
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
9 May 2019
stated in
Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
9 May 2019
stated in
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IBA
biological process
peptidyl-tyrosine phosphorylation
determination method
IEA
ISS
ISO
IMP
IDA
6 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
ISO
retrieved
9 May 2019
stated in
Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IEA
retrieved
9 May 2019
stated in
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
GOA
curator
UniProt
UniProt protein ID
P34152
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IDA
retrieved
9 May 2019
stated in
Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34152
determination method
IDA

Identifiers

RefSeq protein ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21984735&oldid=2023244291"