Crystallin, alpha A (Q21173266)

http://www.ebi.ac.uk/interpro/protein/P24622

Alpha-crystallin, subunit A

1 reference

http://www.ebi.ac.uk/interpro/protein/P24622

Alpha-crystallin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Alpha crystallin/Hsp20 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

unfolded protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

1 reference

14 February 2019

protein binding

3 references

14 February 2019

Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

structural constituent of eye lens

Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

cell component

cytoplasm

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

IDA

14 February 2019

Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

IDA

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

nucleoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

cytosol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

biological process

tubulin complex assembly

1 reference

14 February 2019

Alpha-crystallin expression affects microtubule assembly and prevents their aggregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

14 February 2019

Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

positive regulation of protein phosphorylation

1 reference

14 February 2019

Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

response to hypoxia

1 reference

14 February 2019

Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

actin filament organization

1 reference

14 February 2019

Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

apoptotic process involved in morphogenesis

1 reference

14 February 2019

Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

mitochondrion organization

1 reference

14 February 2019

Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

negative regulation of apoptotic process

1 reference

14 February 2019

Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

response to glucocorticoid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

negative regulation of gene expression

1 reference

14 February 2019

Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

positive regulation of cell growth

1 reference

14 February 2019

The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

lens development in camera-type eye

Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

response to lead ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

lens morphogenesis in camera-type eye

embryonic camera-type eye morphogenesis

1 reference

14 February 2019

Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

microtubule-based process

1 reference

14 February 2019

Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

response to UV-A

1 reference

14 February 2019

The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

camera-type eye development

1 reference

14 February 2019

Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

lens fiber cell morphogenesis

2 references

14 February 2019

Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

apoptotic process

1 reference

14 February 2019

Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

multicellular organism aging

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

response to hydrogen peroxide

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24622

Alpha crystallin/Hsp20 domain

has part(s)

1 reference

http://www.ebi.ac.uk/interpro/protein/P24622

Alpha-crystallin, N-terminal

1 reference