Serine/threonine kinase 3 (Q21173215)

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mammalian protein found in Homo sapiens
  • serine/threonine kinase 3 (STE20 homolog, yeast)
  • epididymis secretory sperm binding protein
  • serine/threonine kinase 3 (Ste20, yeast homolog)
  • STK3
  • STE20-like kinase MST2
  • serine/threonine-protein kinase 3
  • MST-2
  • serine/threonine-protein kinase Krs-1
  • mammalian STE20-like protein kinase 2
  • KB-1458E12.1
edit
Language Label Description Also known as
English
Serine/threonine kinase 3
mammalian protein found in Homo sapiens
  • serine/threonine kinase 3 (STE20 homolog, yeast)
  • epididymis secretory sperm binding protein
  • serine/threonine kinase 3 (Ste20, yeast homolog)
  • STK3
  • STE20-like kinase MST2
  • serine/threonine-protein kinase 3
  • MST-2
  • serine/threonine-protein kinase Krs-1
  • mammalian STE20-like protein kinase 2
  • KB-1458E12.1

Statements

molecular function
protein serine/threonine kinase activity
determination method or standard
EXP
IDA
IEA
10 references
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
IEA
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
IEA
retrieved
27 March 2018
stated in
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
IDA
retrieved
27 March 2018
stated in
Cloning and characterization of a member of the MST subfamily of Ste20-like kinases
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
IDA
retrieved
27 March 2018
stated in
Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
IDA
retrieved
27 March 2018
stated in
RASSF2 associates with and stabilizes the proapoptotic kinase MST2
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
IDA
retrieved
27 March 2018
stated in
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
EXP
retrieved
27 March 2018
stated in
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
EXP
retrieved
27 March 2018
stated in
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
EXP
retrieved
27 March 2018
stated in
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188
determination method or standard
EXP
protein binding
determination method or standard
IPI
19 references
retrieved
8 April 2019
stated in
Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IPI
protein serine/threonine kinase activity
determination method or standard
EXP
IBA
IDA
IEA
11 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IEA
retrieved
8 April 2019
stated in
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cloning and characterization of a member of the MST subfamily of Ste20-like kinases
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IDA
retrieved
8 April 2019
stated in
RASSF2 associates with and stabilizes the proapoptotic kinase MST2
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IDA
retrieved
8 April 2019
stated in
Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1
GOA
curator
UniProt
UniProt protein ID
Q13188
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
IBA
retrieved
8 April 2019
stated in
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
EXP
retrieved
8 April 2019
stated in
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
EXP
retrieved
8 April 2019
stated in
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
EXP
retrieved
8 April 2019
stated in
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188
determination method or standard
EXP
cell component
biological process

Identifiers

MeSH descriptor ID
D000090742
subject named as
Serine-Threonine Kinase 3
0 references
RefSeq protein ID
 
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