LDL receptor related protein 6 (Q21132095)

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mammalian protein found in Homo sapiens
  • LRP6
  • low-density lipoprotein receptor-related protein 6
  • LRP-6
edit
Language Label Description Also known as
English
LDL receptor related protein 6
mammalian protein found in Homo sapiens
  • LRP6
  • low-density lipoprotein receptor-related protein 6
  • LRP-6

Statements

molecular function
Wnt-protein binding
determination method or standard
TAS
IEA
IPI
6 references
stated in
UniProt
UniProt protein ID
O75581
retrieved
9 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
The importance of Wnt signalling for neurodegeneration in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
TAS
retrieved
8 April 2019
stated in
Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
LDL-receptor-related proteins in Wnt signal transduction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IEA
protein binding
determination method or standard
IPI
40 references
stated in
UniProt
UniProt protein ID
O75581
retrieved
9 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
GOA
curator
UniProt
UniProt protein ID
O75581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains
GOA
curator
UniProt
UniProt protein ID
O75581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation
GOA
curator
UniProt
UniProt protein ID
O75581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
GOA
curator
UniProt
UniProt protein ID
O75581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cell cycle control of wnt receptor activation
GOA
curator
UniProt
UniProt protein ID
O75581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway
GOA
curator
UniProt
UniProt protein ID
O75581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural Studies of Wnts and Identification of an LRP6 Binding Site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
LDL-receptor-related proteins in Wnt signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
retrieved
8 April 2019
stated in
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IPI
cell component
plasma membrane
determination method or standard
IEA
IDA
TAS
6 references
stated in
UniProt
UniProt protein ID
O75581
retrieved
9 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IEA
retrieved
8 April 2019
stated in
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
biological process
canonical Wnt signaling pathway
determination method or standard
IDA
IEA
IGI
IMP
TAS
20 references
retrieved
8 April 2019
stated in
The importance of Wnt signalling for neurodegeneration in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
TAS
retrieved
8 April 2019
stated in
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
GOA
curator
UniProt
UniProt protein ID
O75581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IMP
retrieved
8 April 2019
stated in
Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IMP
retrieved
8 April 2019
stated in
LDL-receptor-related proteins in Wnt signal transduction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IMP
retrieved
8 April 2019
stated in
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IEA
retrieved
8 April 2019
stated in
Cell cycle control of wnt receptor activation
GOA
curator
UniProt
UniProt protein ID
O75581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA
retrieved
8 April 2019
stated in
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75581
determination method or standard
IDA

Identifiers

MeSH descriptor ID
D060488
subject named as
Low Density Lipoprotein Receptor-Related Protein-6
0 references
 
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