Ring-box 1 (Q21117428)

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mammalian protein found in Homo sapiens
  • ZYP protein
  • RBX1
  • E3 ubiquitin-protein ligase RBX1
  • RING finger protein 75
  • E3 ubiquitin-protein transferase RBX1
  • RING-box protein 1
  • regulator of cullins 1
  • ring-box 1, E3 ubiquitin protein ligase
  • Protein ZYP
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Language Label Description Also known as
English
Ring-box 1
mammalian protein found in Homo sapiens
  • ZYP protein
  • RBX1
  • E3 ubiquitin-protein ligase RBX1
  • RING finger protein 75
  • E3 ubiquitin-protein transferase RBX1
  • RING-box protein 1
  • regulator of cullins 1
  • ring-box 1, E3 ubiquitin protein ligase
  • Protein ZYP

Statements

molecular function
protein binding
determination method or standard
IPI
22 references
retrieved
8 April 2019
stated in
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
TIP120A associates with cullins and modulates ubiquitin ligase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
cell component
SCF ubiquitin ligase complex
determination method or standard
IDA
ISS
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IEA
retrieved
8 April 2019
stated in
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
The novel human DNA helicase hFBH1 is an F-box protein
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
Cul4A-RING E3 ubiquitin ligase complex
determination method or standard
IDA
6 references
retrieved
8 April 2019
stated in
Identification of a primary target of thalidomide teratogenicity
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
Cul3-RING ubiquitin ligase complex
determination method or standard
IBA
IDA
5 references
retrieved
8 April 2019
stated in
Ubiquitin-dependent regulation of COPII coat size and function
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IBA
biological process
protein ubiquitination
determination method or standard
IDA
IEA
IPI
6 references
retrieved
10 September 2018
stated in
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
10 September 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877
determination method or standard
IEA
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877
determination method or standard
IEA
retrieved
10 September 2018
stated in
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
10 September 2018
stated in
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
10 September 2018
stated in
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877
determination method or standard
IDA
protein ubiquitination
determination method or standard
IDA
IEA
IPI
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
TAS
retrieved
8 April 2019
stated in
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IPI
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IEA
retrieved
8 April 2019
stated in
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA
retrieved
8 April 2019
stated in
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells
GOA
curator
UniProt
UniProt protein ID
P62877
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877
determination method or standard
IDA

Identifiers

 
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