TNF receptor superfamily member 10a (Q21116615)

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mammalian protein found in Homo sapiens

cytotoxic TRAIL receptor
TNF-related apoptosis-inducing ligand receptor 1
TRAIL-R1
tumor necrosis factor receptor superfamily member 10a variant 2
TRAIL receptor 1
tumor necrosis factor receptor superfamily, member 10a
death receptor 4
TNFRSF10A
tumor necrosis factor receptor superfamily member 10A

Language	Label	Description	Also known as
English	TNF receptor superfamily member 10a	mammalian protein found in Homo sapiens	cytotoxic TRAIL receptor TNF-related apoptosis-inducing ligand receptor 1 TRAIL-R1 tumor necrosis factor receptor superfamily member 10a variant 2 TRAIL receptor 1 tumor necrosis factor receptor superfamily, member 10a death receptor 4 TNFRSF10A tumor necrosis factor receptor superfamily member 10A

Statements

1 reference

13 November 2019

UniProt protein ID

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00220

Tumour necrosis factor receptor 10

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00220

Tumor necrosis factor receptor 10, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor receptor 10A/B, death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TNFR/NGFR cysteine-rich region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription factor binding

determination method or standard

1 reference

1 January 2018

Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

protease binding

determination method or standard

1 reference

1 January 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

protein binding

determination method or standard

6 references

1 January 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

tumor necrosis factor-activated receptor activity

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

death receptor activity

determination method or standard

1 reference

1 January 2018

The receptor for the cytotoxic ligand TRAIL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

signaling receptor activity

determination method or standard

1 reference

1 January 2018

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

plasma membrane

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

determination method or standard

1 reference

5 June 2018

N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

integral component of membrane

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

determination method or standard

biological process

activation of NF-kappaB-inducing kinase activity

determination method or standard

2 references

1 January 2018

Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

TRAIL-activated apoptotic signaling pathway

determination method or standard

1 reference

5 June 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

multicellular organism development

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

cell surface receptor signaling pathway

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

cellular response to mechanical stimulus

determination method or standard

1 reference

1 January 2018

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

regulation of cell population proliferation

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

immune response

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

inflammatory response

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

extrinsic apoptotic signaling pathway

determination method or standard

1 reference

1 January 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

tumor necrosis factor-mediated signaling pathway

determination method or standard

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

leukocyte migration

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

regulation of apoptotic process

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

TRAIL-activated apoptotic signaling pathway

determination method or standard

positive regulation of apoptotic process

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

TNFR/NGFR cysteine-rich region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00220

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00220

Tumor necrosis factor receptor 10, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00220

Tumour necrosis factor receptor 10A/B, death domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00220

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000221132

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000221132

ENSP00000428884

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428884

ENSP00000480778

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000480778

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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