Frizzled class receptor 5 (Q21115941)

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mammalian protein found in Homo sapiens

fz-5
fzE5
Wnt receptor
FZD5
frizzled family receptor 5
seven-transmembrane receptor frizzled-5
frizzled-5
frizzled 5, seven transmembrane spanning receptor

Language	Label	Description	Also known as
English	Frizzled class receptor 5	mammalian protein found in Homo sapiens	fz-5 fzE5 Wnt receptor FZD5 frizzled family receptor 5 seven-transmembrane receptor frizzled-5 frizzled-5 frizzled 5, seven transmembrane spanning receptor

Statements

1 reference

13 November 2019

UniProt protein ID

frizzled/secreted frizzled-related protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13467

Frizzled cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13467

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2-like

1 reference

based on heuristic

inferred from protein domain or family

Frizzled-5, CRD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Frizzled domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

amyloid-beta binding

determination method or standard

1 reference

11 April 2017

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

signal transducer activity

determination method or standard

1 reference

11 April 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

Wnt-protein binding

determination method or standard

5 references

11 April 2017

Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

Wnt2b controls retinal cell differentiation at the ciliary marginal zone

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

Wnt2b controls retinal cell differentiation at the ciliary marginal zone

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

protein binding

determination method or standard

3 references

11 April 2017

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

protein kinase binding

determination method or standard

1 reference

11 April 2017

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

ubiquitin protein ligase binding

determination method or standard

1 reference

11 April 2017

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

transmembrane signaling receptor activity

determination method or standard

1 reference

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

Wnt-activated receptor activity

determination method or standard

3 references

11 April 2017

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

A member of the Frizzled protein family mediating axis induction by Wnt-5A

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

G protein-coupled receptor activity

determination method or standard

1 reference

11 April 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

clathrin-coated endocytic vesicle membrane

determination method or standard

1 reference

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

early endosome membrane

determination method or standard

1 reference

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

bicellular tight junction

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

determination method or standard

1 reference

11 April 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

plasma membrane

determination method or standard

determination method or standard

1 reference

11 April 2017

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

perinuclear region of cytoplasm

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

integral component of membrane

determination method or standard

1 reference

11 April 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

biological process

G protein-coupled receptor signaling pathway

determination method or standard

1 reference

11 April 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

T cell differentiation in thymus

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

chorionic trophoblast cell differentiation

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

positive regulation of protein targeting to mitochondrion

determination method or standard

1 reference

11 April 2017

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

positive regulation of JUN kinase activity

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

apoptotic process involved in morphogenesis

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

regulation of chorionic trophoblast cell proliferation

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

regulation of bicellular tight junction assembly

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

regulation of canonical Wnt signaling pathway

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

cellular response to molecule of bacterial origin

determination method or standard

1 reference

11 April 2017

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

positive regulation of interferon-gamma production

determination method or standard

1 reference

11 April 2017

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

embryonic axis specification

determination method or standard

1 reference

11 April 2017

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

labyrinthine layer blood vessel development

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

cell maturation

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

Wnt signaling pathway

determination method or standard

embryonic camera-type eye development

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

multicellular organism development

determination method or standard

1 reference

11 April 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

cell surface receptor signaling pathway

determination method or standard

1 reference

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

vasculature development

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

regulation of autophagy of mitochondrion

determination method or standard

1 reference

11 April 2017

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

branching involved in labyrinthine layer morphogenesis

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

embryonic camera-type eye morphogenesis

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

post-embryonic camera-type eye development

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

positive regulation of T cell cytokine production

determination method or standard

1 reference

11 April 2017

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

neuron differentiation

determination method or standard

1 reference

11 April 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

Wnt signaling pathway involved in dorsal/ventral axis specification

determination method or standard

1 reference

11 April 2017

LDL-receptor-related proteins in Wnt signal transduction

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

canonical Wnt signaling pathway

determination method or standard

5 references

11 April 2017

A member of the Frizzled protein family mediating axis induction by Wnt-5A

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

synapse assembly

determination method or standard

1 reference

11 April 2017

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

syncytiotrophoblast cell differentiation involved in labyrinthine layer development

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

anterior/posterior axis specification, embryo

determination method or standard

1 reference

11 April 2017

A member of the Frizzled protein family mediating axis induction by Wnt-5A

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

Spemann organizer formation

determination method or standard

1 reference

11 April 2017

A member of the Frizzled protein family mediating axis induction by Wnt-5A

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

3 references

11 April 2017

Interaction of Frizzled 7 and Dishevelled in Xenopus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

11 April 2017

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

negative regulation of cell population proliferation

determination method or standard

1 reference

11 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

signal transduction

determination method or standard

1 reference

11 April 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

Wnt signaling pathway, calcium modulating pathway

determination method or standard

1 reference

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

Wnt signaling pathway, planar cell polarity pathway

determination method or standard

1 reference

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

beta-catenin destruction complex disassembly

determination method or standard

1 reference

11 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13467

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000354607

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354607

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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