Poly(ADP-ribose) polymerase 1 (Q21112674)

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mammalian protein found in Homo sapiens
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
  • poly[ADP-ribose] synthase 1
  • ADPRT 1
  • protein poly-ADP-ribosyltransferase PARP1
  • poly(ADP-ribose) synthetase
  • NAD(+) ADP-ribosyltransferase 1
  • poly (ADP-ribose) polymerase family, member 1
  • poly [ADP-ribose] polymerase 1
  • poly(ADP-ribosyl)transferase
  • ARTD1
  • PARP1
  • ADP-ribosyltransferase NAD(+)
  • DNA ADP-ribosyltransferase PARP1
  • ADP-ribosyltransferase diphtheria toxin-like 1
edit
Language Label Description Also known as
English
Poly(ADP-ribose) polymerase 1
mammalian protein found in Homo sapiens
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
  • poly[ADP-ribose] synthase 1
  • ADPRT 1
  • protein poly-ADP-ribosyltransferase PARP1
  • poly(ADP-ribose) synthetase
  • NAD(+) ADP-ribosyltransferase 1
  • poly (ADP-ribose) polymerase family, member 1
  • poly [ADP-ribose] polymerase 1
  • poly(ADP-ribosyl)transferase
  • ARTD1
  • PARP1
  • ADP-ribosyltransferase NAD(+)
  • DNA ADP-ribosyltransferase PARP1
  • ADP-ribosyltransferase diphtheria toxin-like 1

Statements

part of
molecular function
protein binding
determination method
IPI
44 references
retrieved
8 April 2019
stated in
Serine ADP-Ribosylation Depends on HPF1
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Aprataxin, a novel protein that protects against genotoxic stress
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
ZNF365 promotes stalled replication forks recovery to maintain genome stability
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
PARP-1 transcriptional activity is regulated by sumoylation upon heat shock
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction of the Werner syndrome protein with poly‐ADP ribosyl transferase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Poly(ADP-ribose)-dependent regulation of Snail1 protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
In prostate cancer cells the interaction of C/EBPalpha with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of molecular links between core and candidate genes in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
The FHA domain of aprataxin interacts with the C-terminal region of XRCC1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Aprataxin, a novel protein that protects against genotoxic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
retrieved
8 April 2019
stated in
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IPI
NAD+ ADP-ribosyltransferase activity
determination method
IDA
IEA
IMP
TAS
10 references
retrieved
31 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
TAS
retrieved
31 October 2017
stated in
Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
TAS
retrieved
31 October 2017
stated in
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IMP
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
31 October 2017
stated in
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
31 October 2017
stated in
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
31 October 2017
stated in
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
31 October 2017
stated in
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IDA
NAD+ ADP-ribosyltransferase activity
determination method
IBA
IDA
IEA
IMP
TAS
13 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
TAS
retrieved
8 April 2019
stated in
Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
TAS
retrieved
8 April 2019
stated in
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
8 April 2019
stated in
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IBA
protein ADP-ribosylase activity
determination method
IBA
IDA
6 references
retrieved
8 April 2019
stated in
Serine ADP-Ribosylation Depends on HPF1
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Family-wide analysis of poly(ADP-ribose) polymerase activity
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IBA
cell component
nucleus
determination method
IDA
IEA
TAS
7 references
retrieved
31 October 2017
stated in
Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
TAS
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
31 October 2017
stated in
Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
31 October 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
31 October 2017
stated in
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
TAS
8 references
retrieved
8 April 2019
stated in
Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
8 April 2019
stated in
Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IBA
biological process
cellular response to DNA damage stimulus
determination method
IEA
IMP
5 references
retrieved
8 April 2019
stated in
HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IMP
retrieved
8 April 2019
stated in
WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IMP
retrieved
8 April 2019
stated in
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IMP
retrieved
8 April 2019
stated in
Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IEA
protein ADP-ribosylation
determination method
IDA
IEA
IMP
TAS
8 references
retrieved
8 April 2019
stated in
Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
TAS
retrieved
8 April 2019
stated in
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IEA
retrieved
8 April 2019
stated in
HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA
retrieved
8 April 2019
stated in
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
GOA
curator
UniProt
UniProt protein ID
P09874
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874
determination method
IDA

Identifiers

Freebase ID
/m/03ct5c8
0 references
PDB structure ID
 
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