BR serine/threonine kinase 2 (Q21110488)

http://www.ebi.ac.uk/interpro/protein/Q8IWQ3

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

ATPase binding

1 reference

8 April 2019

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

ATPase regulator activity

1 reference

8 April 2019

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

magnesium ion binding

1 reference

8 April 2019

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

tau-protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

26 September 2017

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

3 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

26 September 2017

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

8 April 2019

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

tau protein binding

1 reference

8 April 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

tau-protein kinase activity

Roles of tau protein in health and disease

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

cell component

centrosome

1 reference

26 September 2017

APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

microtubule organizing center

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

perinuclear region of cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

nucleus

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

3 references

26 September 2017

26 September 2017

BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

26 September 2017

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

endoplasmic reticulum

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

4 references

8 April 2019

8 April 2019

BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

centrosome

distal axon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

actin cytoskeleton reorganization

ISS

biological process

1 reference

8 April 2019

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

neuron projection morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

ERAD pathway

1 reference

8 April 2019

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1 reference

8 April 2019

BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

G2/M transition of mitotic cell cycle

1 reference

8 April 2019

APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

peptidyl-serine phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

regulation of ATP-dependent activity

1 reference

8 April 2019

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

regulation of retrograde protein transport, ER to cytosol

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

IC

exocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

1 reference

8 April 2019

regulation of insulin secretion involved in cellular response to glucose stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

3 references

8 April 2019

ISS

8 April 2019

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

3 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

26 September 2017

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWQ3&geneProductId=UniProtKB:Q8IWQ3

neuron differentiation

ISS

3 references

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

axonogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

establishment of cell polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

intracellular signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

regulation of synaptic vesicle clustering

TAS

1 reference

8 April 2019

Microtubule stabilization specifies initial neuronal polarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWQ3

physically interacts with

TAS

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6044

language of work or name

English

http://www.uniprot.org/uniprot/Q8IWQ3.txt?version=138

17 August 2016

EC enzyme number

2.7.11.26

1 reference

14 November 2015

has part(s)

protein kinase domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8IWQ3

protein kinase, ATP binding site

1 reference

http://www.ebi.ac.uk/interpro/protein/Q8IWQ3

serine/threonine-protein kinase, active site

1 reference