lysine demethylase 1A (Q21108161)

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mammalian protein found in Homo sapiens
  • flavin-containing amine oxidase domain-containing protein 2
  • KDM1A
  • BRAF35-HDAC complex protein BHC110
  • FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
  • lysine-specific histone demethylase 1
  • lysine (K)-specific demethylase 1A
  • amine oxidase (flavin containing) domain 2
  • lysine-specific histone demethylase 1A
  • KDM1A protein, human
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Language Label Description Also known as
English
lysine demethylase 1A
mammalian protein found in Homo sapiens
  • flavin-containing amine oxidase domain-containing protein 2
  • KDM1A
  • BRAF35-HDAC complex protein BHC110
  • FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
  • lysine-specific histone demethylase 1
  • lysine (K)-specific demethylase 1A
  • amine oxidase (flavin containing) domain 2
  • lysine-specific histone demethylase 1A
  • KDM1A protein, human

Statements

molecular function
protein binding
determination method or standard
IPI
19 references
retrieved
8 April 2019
stated in
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4
GOA
curator
UniProt
UniProt protein ID
O60341
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors
GOA
curator
UniProt
UniProt protein ID
O60341
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of LSD1-CoREST selectivity in histone H3 recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
The functional interactome landscape of the human histone deacetylase family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Y2H-seq approach defines the human protein methyltransferase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
retrieved
8 April 2019
stated in
TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IPI
chromatin binding
determination method or standard
IBA
IDA
IEA
5 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IEA
retrieved
8 April 2019
stated in
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
GOA
curator
UniProt
UniProt protein ID
O60341
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4
GOA
curator
UniProt
UniProt protein ID
O60341
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IDA
retrieved
8 April 2019
stated in
The histone demethylase LSD1/KDM1A promotes the DNA damage response
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IBA
cell component
nucleus
determination method or standard
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60341
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IEA
retrieved
8 April 2019
stated in
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
GOA
curator
UniProt
UniProt protein ID
O60341
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IDA
retrieved
8 April 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60341
determination method or standard
IBA
biological process

Identifiers

MeSH descriptor ID
C495195
subject named as
KDM1A protein, human
0 references
PDB structure ID
 
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