Actinin alpha 3 (Q21096435)

http://www.ebi.ac.uk/interpro/protein/Q08043

EF-hand domain pair

1 reference

http://www.ebi.ac.uk/interpro/protein/Q08043

EF-hand domain, protein family

1 reference

Calponin homology domain, protein family

1 reference

EF-hand, Ca insensitive, protein family

1 reference

Actinin-type actin-binding domain, conserved site, protein family

1 reference

Spectrin repeat, protein family

1 reference

Spectrin/alpha-actinin, protein family

1 reference

image

Protein ACTN3 PDB 1tjt.png
884 × 525; 287 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

protein homodimerization activity

IEA

1 reference

8 April 2019

Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

transmembrane transporter binding

IPI

1 reference

8 April 2019

Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

IPI

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

IEA

integrin binding

1 reference

8 April 2019

Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

protein binding

IPI

actin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

structural constituent of muscle

IEA

1 reference

8 April 2019

Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

pseudopodium

1 reference

8 April 2019

Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

focal adhesion

1 reference

8 April 2019

Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

intracellular anatomical structure

1 reference

1 January 2018

α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08043&geneProductId=UniProtKB:Q08043

actin filament

1 reference

8 April 2019

Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

extracellular exosome

1 reference

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08043&geneProductId=UniProtKB:Q08043

extracellular exosome

HDA

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

regulation of apoptotic process

HDA

biological process

NAS

1 reference

8 April 2019

Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

regulation of aerobic respiration

NAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

negative regulation of glycolytic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

negative regulation of calcineurin-NFAT signaling cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

transition between fast and slow fiber

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

positive regulation of glucose catabolic process to lactate via pyruvate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

focal adhesion assembly

1 reference

8 April 2019

Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

muscle filament sliding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

skeletal muscle atrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

response to denervation involved in regulation of muscle adaptation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

negative regulation of oxidative phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

positive regulation of skeletal muscle tissue growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

regulation of the force of skeletal muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

1 reference

8 April 2019

negative regulation of cold-induced thermogenesis

1 reference

8 April 2019

Altered Ca2+ kinetics associated with α-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08043

has part(s)

Spectrin/alpha-actinin

1 reference

http://www.ebi.ac.uk/interpro/protein/Q08043

Spectrin repeat

1 reference

http://www.ebi.ac.uk/interpro/protein/Q08043

EF-hand domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q08043

EF-hand, Ca insensitive

1 reference

http://www.ebi.ac.uk/interpro/protein/Q08043

Calponin homology domain

1 reference

http://www.ebi.ac.uk/interpro/protein/Q08043

Actinin-type actin-binding domain, conserved site

1 reference