Potassium inwardly rectifying channel subfamily J member 2 (Q2004050)

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mammalian protein found in Homo sapiens

potassium channel, inwardly rectifying subfamily J, member 2
cardiac inward rectifier potassium channel
Inward rectifier K(+) channel Kir2.1
Potassium channel, inwardly rectifying subfamily J member 2
IRK-1
potassium inwardly-rectifying channel, subfamily J, member 2
potassium voltage-gated channel subfamily J member 2
inward rectifier potassium channel 2
KCNJ2
hIRK1
inward rectifier K+ channel KIR2.1

Language	Label	Description	Also known as
English	Potassium inwardly rectifying channel subfamily J member 2	mammalian protein found in Homo sapiens	potassium channel, inwardly rectifying subfamily J, member 2 cardiac inward rectifier potassium channel Inward rectifier K(+) channel Kir2.1 Potassium channel, inwardly rectifying subfamily J member 2 IRK-1 potassium inwardly-rectifying channel, subfamily J, member 2 potassium voltage-gated channel subfamily J member 2 inward rectifier potassium channel 2 KCNJ2 hIRK1 inward rectifier K+ channel KIR2.1

Statements

1 reference

13 November 2019

UniProt protein ID

inward-rectifier potassium channel

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

determination method or standard

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

voltage-gated ion channel activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

identical protein binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

phosphatidylinositol-4,5-bisphosphate binding

determination method or standard

1 reference

8 April 2019

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

inward rectifier potassium channel activity

determination method or standard

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method or standard

24 April 2018

Direct and Specific Activation of Human Inward Rectifier K+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method or standard

24 April 2018

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method or standard

24 April 2018

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method or standard

G-protein activated inward rectifier potassium channel activity

determination method or standard

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63252&geneProductId=UniProtKB:P63252

determination method or standard

inward rectifier potassium channel activity

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

8 April 2019

Direct and Specific Activation of Human Inward Rectifier K+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

8 April 2019

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

rough endoplasmic reticulum

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

Golgi apparatus

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

intercalated disc

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

voltage-gated potassium channel complex

determination method or standard

1 reference

8 April 2019

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

dendritic spine

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

8 April 2019

Molecular cloning and expression of a human heart inward rectifier potassium channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

smooth endoplasmic reticulum

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

intrinsic component of membrane

determination method or standard

1 reference

8 April 2019

Direct and Specific Activation of Human Inward Rectifier K+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

biological process

cardiac muscle cell action potential

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

regulation of ion transmembrane transport

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

magnesium ion transport

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

cardiac muscle cell action potential involved in contraction

determination method or standard

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

cellular potassium ion homeostasis

determination method or standard

1 reference

8 April 2019

Inwardly rectifying potassium channels: their structure, function, and physiological roles

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

potassium ion transport

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

8 April 2019

Direct and Specific Activation of Human Inward Rectifier K+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

regulation of cardiac muscle cell contraction

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

cellular response to mechanical stimulus

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

membrane repolarization during action potential

determination method or standard

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

potassium ion transmembrane transport

determination method or standard

1 reference

8 April 2019

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

positive regulation of potassium ion transmembrane transport

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

regulation of skeletal muscle contraction via regulation of action potential

determination method or standard

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

regulation of resting membrane potential

determination method or standard

1 reference

8 April 2019

Inwardly rectifying potassium channels: their structure, function, and physiological roles

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

regulation of membrane repolarization

determination method or standard

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

relaxation of skeletal muscle

determination method or standard

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

regulation of heart rate by cardiac conduction

determination method or standard

1 reference

8 April 2019

A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

membrane repolarization during cardiac muscle cell action potential

determination method or standard

protein homotetramerization

determination method or standard

1 reference

8 April 2019

Direct and Specific Activation of Human Inward Rectifier K+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

relaxation of cardiac muscle

determination method or standard

1 reference

8 April 2019

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

membrane depolarization during cardiac muscle cell action potential

determination method or standard

1 reference

8 April 2019

Inwardly rectifying potassium channels: their structure, function, and physiological roles

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

potassium ion import across plasma membrane

determination method or standard

cardiac conduction

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63252

determination method or standard

Gene Atlas image

PBB GE KCNJ2 206765 at fs.png
732 × 530; 10 KB

0 references

http://purl.uniprot.org/uniprot/P63252

1 reference

Identifiers.org

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000243457

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000243457

ENSP00000441848

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441848

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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