Caspase 3 (Q14914375)

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mammalian protein found in Mus musculus
  • SREBP cleavage activity 1
  • caspase-3
  • protein Yama
  • cysteine protease CPP32
  • Casp3
  • apopain
  • LICE
  • caspase 3, apoptosis related cysteine protease
  • SCA-1
  • CPP-32
edit
Language Label Description Also known as
English
Caspase 3
mammalian protein found in Mus musculus
  • SREBP cleavage activity 1
  • caspase-3
  • protein Yama
  • cysteine protease CPP32
  • Casp3
  • apopain
  • LICE
  • caspase 3, apoptosis related cysteine protease
  • SCA-1
  • CPP-32

Statements

molecular function
peptidase activity
determination method
IDA
RCA
IEA
IMP
ISO
11 references
retrieved
9 May 2019
stated in
Comparative analysis of apoptosis and inflammation genes of mice and humans
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
RCA
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
ISO
retrieved
9 May 2019
stated in
Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P70677
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
9 May 2019
stated in
Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Molecular Components of a Cell Death Pathway Activated by Endoplasmic Reticulum Stress
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
p73 is required for survival and maintenance of CNS neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
cysteine-type endopeptidase activity
determination method
IDA
IEA
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
9 May 2019
stated in
Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity
GOA
curator
UniProt
UniProt protein ID
P70677
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
cell component
cytoplasm
determination method
IDA
IEA
ISO
7 references
retrieved
16 July 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
ISO
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P70677
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
16 July 2018
stated in
Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
16 July 2018
stated in
Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
16 July 2018
stated in
Role of prodomain in importin-mediated nuclear localization and activation of caspase-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
16 July 2018
stated in
Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IDA
cytoplasm
determination method
IBA
IDA
IEA
ISO
8 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P70677
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
9 May 2019
stated in
Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Role of prodomain in importin-mediated nuclear localization and activation of caspase-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IBA
biological process
neuron apoptotic process
determination method
IDA
IGI
IMP
6 references
retrieved
9 May 2019
stated in
Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IGI
retrieved
9 May 2019
stated in
BAD is a pro-survival factor prior to activation of its pro-apoptotic function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
p73 is required for survival and maintenance of CNS neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
execution phase of apoptosis
determination method
IDA
IEA
IGI
IMP
ISO
7 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
ISO
retrieved
9 May 2019
stated in
Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IGI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
9 May 2019
stated in
The role of Asp-462 in regulating Akt activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
apoptotic process
determination method
IDA
IEA
IMP
ISO
8 references
retrieved
16 July 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
ISO
retrieved
16 July 2018
stated in
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
16 July 2018
stated in
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
16 July 2018
stated in
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P70677
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
16 July 2018
stated in
Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
16 July 2018
stated in
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70677&geneProductId=UniProtKB:P70677
determination method
IDA
apoptotic process
determination method
IBA
IDA
IEA
IMP
ISO
9 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
ISO
retrieved
9 May 2019
stated in
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P70677
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IEA
retrieved
9 May 2019
stated in
Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70677
determination method
IBA

Identifiers

 
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