BCL2-associated agonist of cell death (Q14907709)

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mammalian protein found in Mus musculus
  • bcl-xL/Bcl-2-associated death promoter
  • bcl2 antagonist of cell death
  • bcl2-associated agonist of cell death
  • Bad
  • bcl-2-binding component 6
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Language Label Description Also known as
English
BCL2-associated agonist of cell death
mammalian protein found in Mus musculus
  • bcl-xL/Bcl-2-associated death promoter
  • bcl2 antagonist of cell death
  • bcl2-associated agonist of cell death
  • Bad
  • bcl-2-binding component 6

Statements

molecular function
protein binding
determination method or standard
IPI
17 references
retrieved
9 May 2019
stated in
Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins
GOA
curator
UniProt
UniProt protein ID
Q61337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells
GOA
curator
UniProt
UniProt protein ID
Q61337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Dual role of proapoptotic BAD in insulin secretion and beta cell survival
GOA
curator
UniProt
UniProt protein ID
Q61337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation
GOA
curator
UniProt
UniProt protein ID
Q61337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells
GOA
curator
UniProt
UniProt protein ID
Q61337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Type IX collagen knock-out mouse shows progressive hearing loss
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
14-3-3 inhibits Bad-induced cell death through interaction with serine-136
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
retrieved
9 May 2019
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IPI
cell component
cytosol
determination method or standard
IDA
IEA
TAS
ISO
5 references
retrieved
27 February 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61337&geneProductId=UniProtKB:Q61337
determination method or standard
TAS
retrieved
27 February 2018
stated in
Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61337&geneProductId=UniProtKB:Q61337
determination method or standard
ISO
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61337&geneProductId=UniProtKB:Q61337
determination method or standard
IEA
retrieved
27 February 2018
stated in
Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61337&geneProductId=UniProtKB:Q61337
determination method or standard
IDA
retrieved
27 February 2018
stated in
Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61337&geneProductId=UniProtKB:Q61337
determination method or standard
IDA
mitochondrion
determination method or standard
HDA
IBA
IDA
IEA
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q61337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IEA
retrieved
9 May 2019
stated in
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IBA
retrieved
9 May 2019
stated in
A mitochondrial protein compendium elucidates complex I disease biology
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
HDA
cytosol
determination method or standard
IBA
IDA
IEA
ISO
TAS
6 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
TAS
retrieved
9 May 2019
stated in
Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IEA
retrieved
9 May 2019
stated in
Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IDA
retrieved
9 May 2019
stated in
Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IBA
cytoplasm
determination method or standard
IDA
IEA
ISO
5 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q61337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IEA
retrieved
9 May 2019
stated in
Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins
GOA
curator
UniProt
UniProt protein ID
Q61337
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IDA
retrieved
9 May 2019
stated in
Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IDA
retrieved
9 May 2019
stated in
Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61337
determination method or standard
IDA
biological process

Identifiers

 
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