Twist basic helix-loop-helix transcription factor 1 (Q14906441)

http://www.ebi.ac.uk/interpro/protein/P26687

Helix-loop-helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26687

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

1 reference

14 February 2019

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

1 reference

14 February 2019

protein homodimerization activity

1 reference

14 February 2019

Twist1 dimer selection regulates cranial suture patterning and fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

protein domain specific binding

1 reference

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

DNA-binding transcription factor activity

1 reference

14 February 2019

Mechanism of transcriptional activation by the proto-oncogene Twist1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

DNA-binding transcription activator activity, RNA polymerase II-specific

transcription factor binding

TAS

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

protein heterodimerization activity

1 reference

14 February 2019

Twist1 dimer selection regulates cranial suture patterning and fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

E-box binding

The sonic hedgehog-patched-gli pathway in human development and disease

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist1 dimer selection regulates cranial suture patterning and fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

protein binding

2 references

14 February 2019

Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

cell component

nucleus

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Biological activities encoded by the murine mesenchymal stem cell transcriptome provide a basis for their developmental potential and broad therapeutic efficacy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

1 reference

14 February 2019

embryonic skeletal system morphogenesis

TAS

biological process

1 reference

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

roof of mouth development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

positive regulation of cell motility

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26687&geneProductId=UniProtKB:P26687

1 reference

24 April 2018

negative regulation of molecular function

1 reference

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

ossification

1 reference

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

rhythmic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

1 reference

14 February 2019

negative regulation of striated muscle tissue development

1 reference

14 February 2019

Expression of a twist-related gene, Bbtwist, during the development of a lancelet species and its relation to cephalochordate anterior structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

aortic valve morphogenesis

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

negative regulation of cell differentiation

1 reference

14 February 2019

Expression of a twist-related gene, Bbtwist, during the development of a lancelet species and its relation to cephalochordate anterior structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

cardiac neural crest cell migration involved in outflow tract morphogenesis

1 reference

14 February 2019

An absence of Twist1 results in aberrant cardiac neural crest morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

cellular response to growth factor stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

muscle organ development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

1 reference

14 February 2019

embryonic digit morphogenesis

1 reference

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

neuron migration

1 reference

14 February 2019

Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

in utero embryonic development

1 reference

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

negative regulation of transcription by RNA polymerase II

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist1 dimer selection regulates cranial suture patterning and fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

M-twist expression inhibits mouse embryonic stem cell-derived myogenic differentiation in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

mitral valve morphogenesis

1 reference

14 February 2019

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

positive regulation of epithelial to mesenchymal transition

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Direct regulation of TWIST by HIF-1alpha promotes metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

hindlimb morphogenesis

1 reference

14 February 2019

Mouse mutants from chemically mutagenized embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26687&geneProductId=UniProtKB:P26687

1 reference

24 April 2018

negative regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

negative regulation of osteoblast differentiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

cardiac neural crest cell development involved in outflow tract morphogenesis

1 reference

14 February 2019

An absence of Twist1 results in aberrant cardiac neural crest morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

cranial suture morphogenesis

3 references

14 February 2019

Twist1 dimer selection regulates cranial suture patterning and fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Craniosynostosis in Twist heterozygous mice: a model for Saethre-Chotzen syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

odontogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

endocardial cushion morphogenesis

1 reference

14 February 2019

An absence of Twist1 results in aberrant cardiac neural crest morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

1 reference

14 February 2019

neural tube closure

1 reference

14 February 2019

twist is required in head mesenchyme for cranial neural tube morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

embryonic limb morphogenesis

3 references

14 February 2019

Mutations of the mouse Twist and sy (fibrillin 2) genes induced by chemical mutagenesis of ES cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist plays an essential role in FGF and SHH signal transduction during mouse limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

negative regulation of skeletal muscle tissue development

negative regulation of oxidative phosphorylation uncoupler activity

1 reference

14 February 2019

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

osteoblast differentiation

1 reference

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

cell proliferation involved in heart valve development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

embryonic cranial skeleton morphogenesis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Mutations of the TWIST gene in the Saethre-Chotzen syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

A twist code determines the onset of osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

negative regulation of tumor necrosis factor production

IGI

1 reference

14 February 2019

Twist mediates suppression of inflammation by type I IFNs and Axl

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

negative regulation of peroxisome proliferator activated receptor signaling pathway

IGI

1 reference

14 February 2019

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

1 reference

14 February 2019

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

negative regulation of histone acetylation

1 reference

14 February 2019

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

bone development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

embryonic forelimb morphogenesis

1 reference

14 February 2019

Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

cellular response to hypoxia

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Direct regulation of TWIST by HIF-1alpha promotes metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

positive regulation of transcription by RNA polymerase II

The sonic hedgehog-patched-gli pathway in human development and disease

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Mechanism of transcriptional activation by the proto-oncogene Twist1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

embryonic hindlimb morphogenesis

1 reference

14 February 2019

Mutations of the TWIST gene in the Saethre-Chotzen syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26687&geneProductId=UniProtKB:P26687

negative regulation of transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Histone acetyltransferase-dependent chromatin remodeling and the vascular clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

negative regulation of apoptotic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26687

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

InterPro Release 71.0