SMAD family member 4 (Q14904159)

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mammalian protein found in Mus musculus
  • mothers against DPP homolog 4
  • mothers against decapentaplegic homolog 4
  • Smad4
  • deletion target in pancreatic carcinoma 4 homolog
  • Smad 4
  • MAD homolog 4
edit
Language Label Description Also known as
English
SMAD family member 4
mammalian protein found in Mus musculus
  • mothers against DPP homolog 4
  • mothers against decapentaplegic homolog 4
  • Smad4
  • deletion target in pancreatic carcinoma 4 homolog
  • Smad 4
  • MAD homolog 4

Statements

molecular function
protein binding
determination method or standard
IPI
10 references
retrieved
9 May 2019
stated in
Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
retrieved
9 May 2019
stated in
Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
retrieved
9 May 2019
stated in
Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
retrieved
9 May 2019
stated in
Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
retrieved
9 May 2019
stated in
Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
retrieved
9 May 2019
stated in
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
retrieved
9 May 2019
stated in
Master transcription factors determine cell-type-specific responses to TGF-β signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
retrieved
9 May 2019
stated in
HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
retrieved
9 May 2019
stated in
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
retrieved
9 May 2019
stated in
Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IPI
DNA-binding transcription factor activity
determination method or standard
IDA
IEA
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IEA
retrieved
9 May 2019
stated in
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
Isl1Cre reveals a common Bmp pathway in heart and limb development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
DNA binding
determination method or standard
IDA
IEA
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97471
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IEA
retrieved
9 May 2019
stated in
A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
Regulation of Hex gene expression by a Smads-dependent signaling pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
cell component
nucleus
determination method or standard
IDA
IEA
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97471
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IEA
retrieved
9 May 2019
stated in
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
biological process
positive regulation of transcription by RNA polymerase II
determination method or standard
IDA
IGI
IEA
IMP
ISO
15 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
ISO
retrieved
9 May 2019
stated in
Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IMP
retrieved
9 May 2019
stated in
Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IMP
retrieved
9 May 2019
stated in
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IMP
retrieved
9 May 2019
stated in
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IMP
retrieved
9 May 2019
stated in
Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IGI
retrieved
9 May 2019
stated in
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IGI
retrieved
9 May 2019
stated in
Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IGI
retrieved
9 May 2019
stated in
Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IGI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IEA
retrieved
9 May 2019
stated in
miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
Isl1Cre reveals a common Bmp pathway in heart and limb development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA
retrieved
9 May 2019
stated in
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471
determination method or standard
IDA

Identifiers

 
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