Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. (Q36859278)

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scientific article published on 28 April 2016

Language	Label	Description	Also known as
English	Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.	scientific article published on 28 April 2016

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scholarly article

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Europe PubMed Central

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16 August 2017

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. (English)

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Europe PubMed Central

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16 August 2017

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Danny Reinberg

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Steven J Gamblin

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16 August 2017

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Jon R Wilson

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author name string

Neil Justin

1

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16 August 2017

Ying Zhang

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16 August 2017

Cataldo Tarricone

3

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16 August 2017

Stephen R Martin

4

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16 August 2017

Shuyang Chen

5

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16 August 2017

Elizabeth Underwood

6

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16 August 2017

Valeria De Marco

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16 August 2017

Lesley F Haire

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Philip A Walker

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16 August 2017

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publication date

28 April 2016

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Nature Communications

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16 August 2017

7

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16 August 2017

11316

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Europe PubMed Central

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16 August 2017

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Creative Commons Attribution 4.0 International

28 April 2016

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April 2022 Public Data File from Crossref

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Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

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Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.

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Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2

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Chromatin repressive complexes in stem cells, development, and cancer

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Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

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PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells.

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Promiscuous RNA binding by Polycomb repressive complex 2.

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The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

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Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

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An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting

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Molecular architecture of human polycomb repressive complex 2

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

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Chromatin-modifying Complex Component Nurf55/p55 Associates with Histones H3 and H4 and Polycomb Repressive Complex 2 Subunit Su(z)12 through Partially Overlapping Binding Sites

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29 September 2017

Histone methylation by PRC2 is inhibited by active chromatin marks

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29 September 2017

The Polycomb complex PRC2 and its mark in life

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29 September 2017

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

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Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies

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29 September 2017

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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29 September 2017

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Role of the polycomb protein EED in the propagation of repressive histone marks

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Mechanisms of polycomb gene silencing: knowns and unknowns

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AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2.

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Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

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The complex language of chromatin regulation during transcription

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Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation

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7 January 2021

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10.1038/NCOMMS11316

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16 August 2017

2016NatCo...711316J

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Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

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Europe PubMed Central

PMC publication ID

16 August 2017

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