Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src (Q24320223)

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English	Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src	scientific article

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scholarly article

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Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src (English)

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PTK2 protein tyrosine kinase 2

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GOA release 2020-03-11

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author name string

D D Schlaepfer

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T Hunter

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language of work or name

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publication date

16 May 1997

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Journal of Biological Chemistry

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272

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20

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13189-95

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Calcium influx induces neurite growth through a Src-Ras signaling cassette

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The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

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Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway

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A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

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Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

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Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.

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Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

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A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.

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A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

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Three-dimensional structure of the tyrosine kinase c-Src

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pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

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Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin

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Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

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Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas

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Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily

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Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain

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Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase

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p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase

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Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization

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Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected].

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Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase.

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Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase

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Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

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Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice

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Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions

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Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.

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The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases

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Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

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Regulation of cell motility by mitogen-activated protein kinase

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Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain

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Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation

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Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1

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Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation

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c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

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Integrins and signal transduction pathways: the road taken

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Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

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Csk suppression of Src involves movement of Csk to sites of Src activity

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Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

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Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

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Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

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Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

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Integrins: emerging paradigms of signal transduction

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Focal adhesions, contractility, and signaling

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10.1074/JBC.272.20.13189

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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