LAG3
Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. In soluble form it is also being developed as a cancer drug in its own right.
Gene
The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. The gene for LAG-3 lies adjacent to the gene for CD4 on human chromosome 12 (12p13) and is approximately 20% identical to the CD4 gene
Protein
The LAG3 protein, which belongs to immunoglobulin (Ig) superfamily, comprises a 503-amino acid type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4. When human LAG-3 was cloned in 1990 it was found to have approx. 70% homology with murine LAG3. The homology of pig LAG3 is 78%.
Podcasts:
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by Lucky Gaucho
Make It Good
by: Lucky GauchoDoes it take you by surprise
This time's gone for real?
Does it make you realize
This time's gone for real?
Alright Alright
No deal...
Gotta take a little time
And make her smile a little
Get the moon and make it shine
Move up and down to please her
Alright Alright
No teasers...
Alright Alright
No No teasers...
And she's real gone...
When you're feelin' kinda wild,
Alone, unsatisfied,
It's time to make it good to yourself...
Be yourself
After five the field's alive,
C'mon it's a free ride.
Tonite she'll be a lady...
But... This time you should make it good
(C'mon Little Joe...)
Make your move before the dawn
And rid your mind of riddles...
Keep on rollin' till you're done
And shake your bones a little...
Showdown Showdown
No needles...
Showdown Showdown
No No needles...
Are you comin' back for more?
When you're feelin' kinda wild,
Alone, unsatisfied,
It's time to make it good to yourself...
After five the field's alive,
C'mon it's a free ride.
Tonite she'll be a lady...
But... This time you should make it good
When you're feeling kinda wild,
Alone, unsatisfied,
Spend a little time on yourself...
Be yourself
When a little ain't enough,
Who's gonna take it off
When you're feelin' kinda wild,
Alone, unsatisfied,
Ain't nothing like having a good time, yeah
After five the field's alive,
C'mon it's a free ride.
Tonite she'll be a lady...
C'mon it's a free ride!
But... This time you should make it good
Dream on...
We're gonna have a good time...
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