| Lymphocyte-activation gene 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | LAG3; CD223 | ||||||||||||
| External IDs | OMIM: 153337 MGI: 106588 HomoloGene: 1719 GeneCards: LAG3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3902 | 16768 | |||||||||||
| Ensembl | ENSG00000089692 | ENSMUSG00000030124 | |||||||||||
| UniProt | P18627 | Q61790 | |||||||||||
| RefSeq (mRNA) | NM_002286.5 | NM_008479.2 | |||||||||||
| RefSeq (protein) | NP_002277.4 | NP_032505.1 | |||||||||||
| Location (UCSC) | Chr 12: 6.88 – 6.89 Mb |
Chr 6: 124.85 – 124.86 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Lymphocyte-activation gene 3, also known as LAG3, is a protein which in humans is encoded by the LAG3 gene.[1][2] LAG3 has also recently been designated CD223 (cluster of differentiation 223).
Lymphocyte-activation protein 3 belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.[1]
References [link]
- ^ a b "Entrez Gene: LAG3 lymphocyte-activation gene 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3902.
- ^ Triebel F, Jitsukawa S, Baixeras E, Roman-Roman S, Genevee C, Viegas-Pequignot E, Hercend T (May 1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171 (5): 1393–405. DOI:10.1084/jem.171.5.1393. PMC 2187904. PMID 1692078. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2187904.
Further reading [link]
- Triebel F (2004). "LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination". Trends Immunol. 24 (12): 619–22. DOI:10.1016/j.it.2003.10.001. PMID 14644131.
- Baixeras E, Huard B, Miossec C et al. (1992). "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens". J. Exp. Med. 176 (2): 327–37. DOI:10.1084/jem.176.2.327. PMC 2119326. PMID 1380059. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2119326.
- Triebel F, Jitsukawa S, Baixeras E et al. (1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171 (5): 1393–405. DOI:10.1084/jem.171.5.1393. PMC 2187904. PMID 1692078. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2187904.
- Blum MD, Wong GT, Higgins KM et al. (1993). "Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer". J. Exp. Med. 177 (5): 1343–58. DOI:10.1084/jem.177.5.1343. PMC 2191022. PMID 8097522. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2191022.
- Huard B, Mastrangeli R, Prigent P et al. (1997). "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5744–9. DOI:10.1073/pnas.94.11.5744. PMC 20850. PMID 9159144. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20850.
- Bruniquel D, Borie N, Triebel F (1998). "Genomic organization of the human LAG-3/CD4 locus". Immunogenetics 47 (1): 96–8. DOI:10.1007/s002510050332. PMID 9382927.
- Bruniquel D, Borie N, Hannier S, Triebel F (1998). "Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II". Immunogenetics 48 (2): 116–24. DOI:10.1007/s002510050411. PMID 9634475.
- Hannier S, Tournier M, Bismuth G, Triebel F (1998). "CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling". J. Immunol. 161 (8): 4058–65. PMID 9780176.
- Hannier S, Triebel F (1999). "The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes". Int. Immunol. 11 (11): 1745–52. DOI:10.1093/intimm/11.11.1745. PMID 10545478.
- Iouzalen N, Andreae S, Hannier S, Triebel F (2001). "LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway". Eur. J. Immunol. 31 (10): 2885–91. DOI:10.1002/1521-4141(2001010)31:10<2885::AID-IMMU2885>3.0.CO;2-2. PMID 11592063.
- Andreae S, Piras F, Burdin N, Triebel F (2002). "Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223)". J. Immunol. 168 (8): 3874–80. PMID 11937541.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Andreae S, Buisson S, Triebel F (2003). "MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223)". Blood 102 (6): 2130–7. DOI:10.1182/blood-2003-01-0273. PMID 12775570.
- Cai XF, Tao Z, Yan ZQ et al. (2004). "Molecular cloning, characterisation and tissue-specific expression of human LAG3, a member of the novel Lag1 protein family". DNA Seq. 14 (2): 79–86. PMID 12825348.
- Gandhi MK, Lambley E, Duraiswamy J et al. (2006). "Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients". Blood 108 (7): 2280–9. DOI:10.1182/blood-2006-04-015164. PMID 16757686.
- Lundmark F, Harbo HF, Celius EG et al. (2007). "Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations". J. Neuroimmunol. 180 (1–2): 193–8. DOI:10.1016/j.jneuroim.2006.08.009. PMID 17020785.
External links [link]
- LAG3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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