LAG3
Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. In soluble form it is also being developed as a cancer drug in its own right.
Gene
The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. The gene for LAG-3 lies adjacent to the gene for CD4 on human chromosome 12 (12p13) and is approximately 20% identical to the CD4 gene
Protein
The LAG3 protein, which belongs to immunoglobulin (Ig) superfamily, comprises a 503-amino acid type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4. When human LAG-3 was cloned in 1990 it was found to have approx. 70% homology with murine LAG3. The homology of pig LAG3 is 78%.
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by: La CucaEs una cara? No!
Es una Pizza? No!
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Es una Pizza? No!
Es la Senhorita cara de Pizza!!!
Dicen que su madre durante el embarazo
Se comio diez pizzas de un chingadazo
Andan diciendo que es una mutante
(A mi no me interesa yo quiero ser su amante)
Senhorita Cara de Pizza
Yo te amo Cara de Pizza
(Eres un amor)
Tiene un corazon que es la envidia de cualquiera
Yo la adorara hasta el dia en que se muriera
Ella es una belleza (ella si tiene cabeza)
Ella si que me emociona (ella es buena persona)
Ella si se ve sabrosa (yo quiero que sea mi esposa)
Senhorita Cara de Pizza
Yo te amo Cara de Pizza
Es como apreciar una obra de arte
Picasso la tendria como unico estandarte
Quiero estirarle sus cachetes de queso
En su boquita de pimiento yo quiero darle un beso
Yo la adoraria de cualquier manera
Con mariscos en la cara a la marinera!
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Yo te amo Cara de Pizza
Senhorita Cara de Pizza
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(Eres un amor)
Ahora voy a verla y voy bien alimentado
No vaya a pasar lo que paso aquel dia pasado
Llegue con mucha hambre y le chingue una rebanada
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