Извор странице Supstituisani amfetamin

{{Drugclassbox-lat
| Image    = Racemic amphetamine.svg
| Alt      = Racemični skelet amfetamina
| Caption = Skeleton [[амфетамин|racemskog amfetamina]] 
| Chemical_class = Supstituisani derivati amfetamina
}}
{| class="infobox"
|+ [[Хиралност молекула|Optički izomeri]] [[амфетамин|amfetamina]] 
|-
|[[File:L-amphetamine.svg|100px]]||[[File:D-amphetamine.svg|100px]]
|-
|[[File:L-amphetamine-3D-vdW.png|100px]]||[[File:D-amphetamine-3D-vdW.png|100px]]
|-
|[[levoamfetamin|<small>L</small>-amfetamin]]||[[dekstroamfetamin|<small>D</small>-amfetamin]]
|}
'''Supstituisani amfetamini''' u [[hemijska klasifikacija|klasa jedinjenja]] bazirana na [[амфетамин|amfetaminskoj]] strukturi;<ref name="Amphetamine - a substituted amphetamine" /> to uključuje sva [[derivat (hemija)|derivatna]] jedinjenja koja nastaju zamenom, ili [[supstitucija (hemija)|supstitucijom]], jednog ili više [[водоник|atoma vodonika]] u strukturi jezgra amfetamina sa [[supstituent]]ima.<ref name="Amphetamine - a substituted amphetamine">{{cite journal | vauthors = Hagel JM, Krizevski R, Marsolais F, Lewinsohn E, Facchini PJ | title = Biosynthesis of amphetamine analogs in plants | journal = Trends Plant Sci. | volume = 17 | issue = 7 | pages = 404–412 | date = 2012 | pmid = 22502775 | doi = 10.1016/j.tplants.2012.03.004 | quote = Substituted amphetamines, which are also called phenylpropylamino alkaloids, are a diverse group of nitrogen-containing compounds that feature a phenethylamine backbone with a methyl group at the α-position relative to the nitrogen (Figure 1). Countless variation in functional group substitutions has yielded a collection of synthetic drugs with diverse pharmacological properties as stimulants, empathogens and hallucinogens [3].&nbsp;... Beyond (1''R'',2''S'')-ephedrine and (1''S'',2''S'')-pseudoephedrine, myriad other substituted amphetamines have important pharmaceutical applications. The stereochemistry at the α-carbon is often a key determinant of pharmacological activity, with (''S'')-enantiomers being more potent. For example, (''S'')-amphetamine, commonly known as d-amphetamine or dextroamphetamine, displays five times greater psychostimulant activity compared with its (''R'')-isomer [78]. Most such molecules are produced exclusively through chemical syntheses and many are prescribed widely in modern medicine. For example, (''S'')-amphetamine (Figure 4b), a key ingredient in Adderall and Dexedrine, is used to treat attention deficit hyperactivity disorder (ADHD) [79].&nbsp;... <br />[Figure 4](b) Examples of synthetic, pharmaceutically important substituted amphetamines.}}</ref><ref name="Substituted amphetamines">{{cite book | author = Glennon RA |veditors=Lemke TL, Williams DA, Roche VF, Zito W | title=Foye's principles of medicinal chemistry | date=2013 | publisher=Wolters Kluwer Health/Lippincott Williams & Wilkins | location=Philadelphia, USA | isbn=9781609133450 | pages=646–648 | edition=7th | section-url=https://books.google.com/books?id=Sd6ot9ul-bUC&q=substituted%20derivatives%20substituents%20amphetamine%20substitution&pg=PA646 | section=Phenylisopropylamine stimulants: amphetamine-related agents | quote = The simplest unsubstituted phenylisopropylamine, 1-phenyl-2-aminopropane, or amphetamine, serves as a common structural template for hallucinogens and psychostimulants. Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class (39).}}</ref><ref name="pmid1855720">{{cite journal | vauthors = Lillsunde P, Korte T | title = Determination of ring- and N-substituted amphetamines as heptafluorobutyryl derivatives | url = https://archive.org/details/sim_forensic-science-international_1991-03_49_2/page/205 | journal = Forensic Sci. Int. | volume = 49 | issue = 2 | pages = 205–213 | date = March 1991 | pmid = 1855720 | doi=10.1016/0379-0738(91)90081-s}}</ref><ref>{{Cite journal|last1=Custodio|first1=Raly James Perez|last2=Botanas|first2=Chrislean Jun|last3=Yoon|first3=Seong Shoon|last4=Peña|first4=June Bryan de la|last5=Peña|first5=Irene Joy dela|last6=Kim|first6=Mikyung|last7=Woo|first7=Taeseon|last8=Seo|first8=Joung-Wook|last9=Jang|first9=Choon-Gon|last10=Kwon|first10=Yong Ho|last11=Kim|first11=Nam Yong|date=2017-11-01|title=Evaluation of the Abuse Potential of Novel Amphetamine Derivatives with Modifications on the Amine (NBNA) and Phenyl (EDA, PMEA, 2-APN) Sites|journal=Biomolecules & Therapeutics|language=en|volume=25|issue=6|pages=578–585|doi=10.4062/biomolther.2017.141|issn=2005-4483|pmc=5685426|pmid=29081089}}</ref> Jedinjenja u ovoj klasi obuhvataju različite farmakološke podklase, uključujući [[психостимуланс|stimulante]], [[Empathogen-entactogen|empatogene]] i [[halucinogeni|halucinogene]], između ostalog.<ref name="Substituted amphetamines" /> Primeri supstituisanih amfetamina su amfetamin (sam),<ref name="Amphetamine - a substituted amphetamine" /><ref name="Substituted amphetamines" /> [[метамфетамин|metamfetamin]],<ref name="Amphetamine - a substituted amphetamine" /> [[efedrin]],<ref name="Amphetamine - a substituted amphetamine" /> [[katinon]],<ref name="Amphetamine - a substituted amphetamine" /> [[fentermin]],<ref name="Amphetamine - a substituted amphetamine" /> [[mefentermin]],<ref name="Amphetamine - a substituted amphetamine" /> [[tranilcipromin]],<ref name="ulrich2017">{{ cite journal | vauthors = Ulrich S, Ricken R, Adli M | journal=European Neuropsychopharmacology | title=Tranylcypromine in mind (Part I): Review of pharmacology | year=2017 | volume=27 | issue=8 | pages=697–713 | doi=10.1016/j.euroneuro.2017.05.007| pmid=28655495 | s2cid=4913721 | doi-access=free }}</ref> [[bupropion]],<ref name="Amphetamine - a substituted amphetamine" /> [[metoksifenamin]],<ref name="Amphetamine - a substituted amphetamine" /> [[selegilin]],<ref name="Amphetamine - a substituted amphetamine" /> [[amfepramon]] (dietilpropion),<ref name="Amphetamine - a substituted amphetamine" /> [[pirovaleron]],<ref name="Amphetamine - a substituted amphetamine" /> [[MDMA]] (ekstazi) i [[2,5-Dimetoksi-4-metilamfetamin|DOM]] (STP).

== Reference ==
{{Reflist|}}

== Literatura ==
{{Литература|30em}}
* {{cite book|last=Ghodse|first=Hamid|title = Drugs and Addictive Behaviour. A Guide to Treatment. 3rd Edition|url = https://books.google.com/books?id=3WF79shLxB4C&pg=PP1|year = 2002|publisher = Cambridge University Press|pages = 501|isbn = 978-0-511-05844-8}}
* {{cite book|author = Glennon, Richard A. |title = The American Psychiatric Publishing textbook of substance abuse treatment|chapter = Neurobiology of Hallucinogens|chapter-url = https://books.google.com/books?id=6wdJgejlQzYC&pg=PA181|year = 2008|publisher = American Psychiatric Publishing|isbn = 978-1-58562-276-4}}
* {{cite book|author1=Goldfrank, Lewis R.  |last2=Flomenbaum|first2=Neal|title = Goldfrank's Toxicologic Emergencies, 8th Edition|url = https://books.google.com/books?id=cvJuLqBxGUcC&pg=PP1|year = 2006|publisher = McGraw Hill|isbn = 978-0-07-147914-1}}
* {{cite book|author = Katzung, Bertram G.|title = Basic & clinical pharmacology. 11th edition|url = https://books.google.com/books?id=srRLpM5miGYC&pg=PP1|year = 2009|publisher = McGraw-Hill Medical|isbn = 978-0-07-160405-5}}{{Мртва веза}}
* {{cite book|last=Ledgard|first=Jared|title = A Laboratory History of Narcotics. Volume 1. Amphetamines and Derivatives|year = 2007|publisher = Jared Ledgard|pages = 268|isbn = 978-0-615-15694-1}}
* {{cite book|author1=Schatzberg, Alan F.  |author2=Nemeroff, Charles B. |title = The American Psychiatric Publishing Textbook of Psychopharmacology|url = https://books.google.com/books?id=Xx7iNGdV25IC&pg=PP1|year = 2009|publisher = The American Psychiatric Publishing|isbn = 978-1-58562-309-9}}
* {{cite book|last=Snow|first=Otto|title = Amphetamine syntheses|url=https://archive.org/details/amphetaminesynth0000snow|year = 2002|publisher = Thoth Press|isbn = 978-0-9663128-3-6}}
* {{cite book|vauthors=Veselovskaya NV, Kovalenko AE |title = Drugs. Properties, effects, pharmacokinetics, metabolism|year = 2000|location = MA|publisher = Triada-X|isbn = 978-5-94497-029-9}}
{{Литература крај}}

== Spoljašnje veze ==
*{{Commons category-inline|Substituted amphetamines}}

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{{СОРТИРАЊЕ:Supstituisani amfetamin}}
[[Категорија:Супституисани амфетамини| ]]
[[Категорија:Амфетамин]]